Dietary Phenolic Compounds Interfere with the Fate of Hydrogen Peroxide in Human Adipose Tissue but Do Not Directly Inhibit Primary Amine Oxidase Activity

Oxidative Medicine and Cellular Longevity
C CarpénéMaria P Portillo

Abstract

Resveratrol has been reported to inhibit monoamine oxidases (MAO). Many substrates or inhibitors of neuronal MAO interact also with other amine oxidases (AO) in peripheral organs, such as semicarbazide-sensitive AO (SSAO), known as primary amine oxidase, absent in neurones, but abundant in adipocytes. We asked whether phenolic compounds (resveratrol, pterostilbene, quercetin, and caffeic acid) behave as MAO and SSAO inhibitors. AO activity was determined in human adipose tissue. Computational docking and glucose uptake assays were performed in 3D models of human AO proteins and in adipocytes, respectively. Phenolic compounds fully inhibited the fluorescent detection of H2O2 generated during MAO and SSAO activation by tyramine and benzylamine. They also quenched H2O2-induced fluorescence in absence of biological material and were unable to abolish the oxidation of radiolabelled tyramine and benzylamine. Thus, phenolic compounds hampered H2O2 detection but did not block AO activity. Only resveratrol and quercetin partially impaired MAO-dependent [(14)C]-tyramine oxidation and behaved as MAO inhibitors. Phenolic compounds counteracted the H2O2-dependent benzylamine-stimulated glucose transport. This indicates that various phenolic...Continue Reading

References

Dec 31, 1997·Analytical Biochemistry·M Zhou, N Panchuk-Voloshina
Feb 14, 2002·Free Radical Biology & Medicine·Albert Y SunGrace Y Sun
Mar 27, 2004·Obesity Research·Virgile VisentinChristian Carpéné
Jan 26, 2006·American Journal of Physiology. Endocrinology and Metabolism·Hui-Chen SuJan-Kan Chen
Feb 4, 2006·Current HIV Research·Yee-Joo TanWanjin Hong
Apr 25, 2006·Biochemical and Biophysical Research Communications·Matilde YáñezFrancisco Orallo
Dec 5, 2006·ChemMedChem·Francesc YraolaMiriam Royo
Oct 4, 2007·Annals of the New York Academy of Sciences·David J Smith, Petri J Vainio
Nov 6, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C CarpénéP Valet
Aug 9, 2008·Phytotherapy Research : PTR·Srujana RayalamClifton A Baile
Nov 18, 2008·Journal of Ethnopharmacology·Lasse SaabyAnna K Jäger
Jan 16, 2009·International Journal of Immunopathology and Pharmacology·T MarteliusI Lautenschlager
Feb 10, 2009·Molecular Pharmacology·Françoise ChicheBruno Fève
Aug 15, 2009·Biochemical and Biophysical Research Communications·José SerranoManuel Portero-Otín
Apr 1, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ying XuWilliam O Ogle
Apr 2, 2010·Journal of Physiology and Biochemistry·E WanecqC Carpéné
Jun 17, 2011·Expert Opinion on Therapeutic Patents·Petra DunkelPéter Mátyus
Dec 3, 2011·Cerebrovascular Diseases·Mar Hernandez-GuillamonJoan Montaner
Jan 28, 2012·ACS Medicinal Chemistry Letters·Claudia BindaDale E Edmondson
Sep 11, 2012·American Journal of Therapeutics·Saleem K Al-NuaimiGlen B Baker
Jan 15, 2013·Journal of Physiology and Biochemistry·Saioa Gomez-ZoritaChristian Carpéné
Feb 8, 2013·Molecular Nutrition & Food Research·Sandra GrèsChristian Carpéné
Feb 16, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mee-Sook SongGlen B Baker
Aug 15, 2013·The Journal of Pharmacology and Experimental Therapeutics·Jonathan S FootWolfgang Jarolimek
Oct 10, 2013·Database : the Journal of Biological Databases and Curation·Joseph A RothwellAugustin Scalbert
Aug 21, 2014·Current Medicinal Chemistry·J MirandaM P Portillo
Aug 21, 2014·Current Medicinal Chemistry·C CarpeneM A Carpene
Jan 7, 2015·The Journal of Clinical Investigation·Chris J WestonDavid H Adams

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Methods Mentioned

BETA
Assay
deamination
Fluorescence

Software Mentioned

Glide
Schrödinger
GraphPad Prism

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