Dietary phosphate toxicity: an emerging global health concern

Histochemistry and Cell Biology
Sarah Erem, Mohammed S Razzaque

Abstract

Phosphate is a common ingredient in many healthy foods but, it is also present in foods containing additives and preservatives. When found in foods, phosphate is absorbed in the intestines and filtered from the blood by the kidneys. Generally, any excess is excreted in the urine. In renal pathologies, however, such as chronic kidney disease, a reduced renal ability to excrete phosphate can result in excess accumulation in the body. This accumulation can be a catalyst for widespread damage to the cellular components, bones, and cardiovascular structures. This in turn can reduce mortality. Because of an incomplete understanding of the mechanism for phosphate homeostasis, and the multiple organ systems that can modulate it, treatment strategies designed to minimize phosphate burden are limited. The Recommended Dietary Allowance (RDA) for phosphorous is around 700 mg/day for adults, but the majority of healthy adult individuals consume far more phosphate (almost double) than the RDA. Studies suggest that low-income populations are particularly at risk for dietary phosphate overload because of the higher amounts of phosphate found in inexpensive, processed foods. Education in nutrition, as well as access to inexpensive healthy food ...Continue Reading

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Citations

May 30, 2020·Journal of Population Therapeutics and Clinical Pharmacology Journal De La Thérapeutique Des Populations Et De La Pharamcologie Clinique·Mohammed S Razzaque
Dec 6, 2018·Nutrients·Mohammed S Razzaque
Jul 7, 2020·Acta Histochemica Et Cytochemica·Nuraly S AkimbekovMohammed S Razzaque
Apr 3, 2020·Nutrients·Anne Marie UwitonzeMohammed S Razzaque
May 1, 2020·Physiological Reviews·Nati HernandoEleanor Lederer
Dec 6, 2020·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
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Mar 15, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Luis Miguel Lou ArnalAlejandro Sanz París
Jul 2, 2021·Frontiers in Veterinary Science·Xiaopeng TangHu Liu
Sep 4, 2021·International Journal of Nephrology and Renovascular Disease·Yaser AmmarDalia Maharem
Oct 8, 2021·The American Journal of Clinical Nutrition·Linshuoshuo LvYingying Mao
Oct 14, 2020·Kidney & Blood Pressure Research·Isabel Rubio-Aliaga

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