Dietary phosphorus restriction to half the minimum required amount slightly reduces weight gain and length of tibia, but sustains femur mineralization and prevents nephrocalcinosis in female kittens

The British Journal of Nutrition
F J PastoorA C Beynen

Abstract

The effects of dietary P restriction to half the recommended minimum level on growth, bone and renal mineralization and urinary composition were studied in female kittens. In two separate experiments, 8-week-old weanling kittens were fed on purified diets containing either 4.6 or 9.2 mmol P/MJ (2.8 or 5.6 g P/kg diet). In the second experiment there was an additional low-P diet in which the Ca concentration was reduced from 9.5 to 4.8 mmol/MJ (7.5 v. 3.8 g Ca/kg diet). P restriction slightly but systematically reduced weight gain (to a maximum of 16%) and growth of the tibia (by 1-4%); the former effect was statistically significant (P < 0.05) between the ages of 15 and 20 weeks in Expt 1 only, and the latter did not reach statistical significance at any time point (P > or = 0.13). No adverse effect of P restriction was found on mineralization of femur at the age of 39 weeks. Kidney Ca concentrations were significantly lowered (Expt 1, 6 v. 20 mumol/g dry weight, P < 0.001; Expt 2, 7 v. 16 mumol/g dry weight, P < 0.01) in cats fed on the low-P diets, this effect not being affected by the dietary Ca:P ratio. Urinary P concentration was significantly depressed (by 50-96%) after feeding the low-P diets (P < 0.001). P intake did no...Continue Reading

References

Feb 1, 1977·The Journal of Nutrition·C J Carey, J G Morris
May 1, 1991·Biological Trace Element Research·H N GrootenA C Beynen
Nov 1, 1991·The Journal of Nutrition·F J PastoorA C Beynen
Oct 1, 1989·The Journal of Nutrition·J Ritskes-HoitingaA C Beynen
Jun 1, 1980·The Journal of Nutrition·G Schaafsma, R Visser

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Citations

Jul 5, 2008·Annual Review of Nutrition·George C FaheyKelly S Swanson
Jun 4, 2002·The Journal of Nutrition·Y H CottamW H Hendriks

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