Abstract
The increased number of elderly people worldwide poses a major medical and socio-economic challenge: the search of strategies to combat the consequences of the aging process. Oxidative stress and inflammation have been pointed out as the leading causes of brain aging, which in turn alters the functionality of brain. In this context, decline in adult neurogenesis (AN), due to modifications in the neural progenitor stem cells (NSCs) and their microenvironment, is among the aging alterations contributing to cognitive decline. Therefore, the consumption or administration of antioxidant and anti-inflammatory molecules, such as dietary polyphenols, is under study as a potential beneficial strategy for preventing brain aging alterations including AN decline. Polyphenols, through their antioxidant and anti-inflammatory properties, modulate several cascades and effectors involved in the regulation of AN (e.g., SIRT1, Wnt, NF-κB and Nrf2, among others). This work summarizes the latest discoveries regarding the mechanisms whereby polyphenols preserve AN and counteract the cognitive decline present in aging.
Citations
Dec 13, 2019·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Jennifer L RobinsonZbigniew J Pietrzkowski
Feb 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giorgio D'AndreaFelice Tirone
Feb 25, 2020·Food & Function·Milda KeršienėDaiva Leskauskaitė
Jan 30, 2020·Nutrients·Margarita R RamisDavid Moranta
May 31, 2020·Cells·Ching-Chi ChangChih-Li Lin
Aug 12, 2020·Drug Development Research·Jin-Mei QiuZhi-Zhong Xie
May 6, 2020·Nutrients·Giuseppe AnnunziataXavier Capó
May 14, 2020·Nutrients·Assylzhan YessenkyzyTalgat Nurgozhin
Apr 23, 2020·Frontiers in Cell and Developmental Biology·Manuela CeccarelliFelice Tirone
Aug 6, 2019·Frontiers in Cell and Developmental Biology·Sabrina PicocciGianfranco Gennarini
Jun 21, 2019·Molecular Nutrition & Food Research·Dorrain Yanwen LowClaudine Manach
Nov 18, 2020·Stem Cell Research & Therapy·Zhaoli HuSuhua Qi
Oct 9, 2020·The British Journal of Nutrition·Leticia GoniEstefanía Toledo
Jul 14, 2019·Molecular Metabolism·Ebrahim SamodienNireshni Chellan
Dec 17, 2020·ChemMedChem·Valeria RomanucciGiovanni Di Fabio
Jan 28, 2021·Antioxidants·Jennifer L RobinsonDarren T Beck
Nov 19, 2020·Antioxidants·Snjezana PetrovicVesna Vucic
Jan 21, 2021·Antioxidants·Juan Ángel CarrilloJavier Marhuenda
Nov 17, 2020·Brain Research Bulletin·Chujie QuJunjian Zhang
Dec 19, 2020·IBRO Reports·Daniel Silva MoraesSérgio Henrique Sousa Santos
Mar 31, 2021·Brain Plasticity·Daniel Joseph Lamport, Claire Michelle Williams
Jul 11, 2021·Neuroscience and Biobehavioral Reviews·Giuseppe AnnunziataSeyed Mohammad Nabavi