Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition

Neuroscience and Biobehavioral Reviews
F SarubboG Pani

Abstract

The increased number of elderly people worldwide poses a major medical and socio-economic challenge: the search of strategies to combat the consequences of the aging process. Oxidative stress and inflammation have been pointed out as the leading causes of brain aging, which in turn alters the functionality of brain. In this context, decline in adult neurogenesis (AN), due to modifications in the neural progenitor stem cells (NSCs) and their microenvironment, is among the aging alterations contributing to cognitive decline. Therefore, the consumption or administration of antioxidant and anti-inflammatory molecules, such as dietary polyphenols, is under study as a potential beneficial strategy for preventing brain aging alterations including AN decline. Polyphenols, through their antioxidant and anti-inflammatory properties, modulate several cascades and effectors involved in the regulation of AN (e.g., SIRT1, Wnt, NF-κB and Nrf2, among others). This work summarizes the latest discoveries regarding the mechanisms whereby polyphenols preserve AN and counteract the cognitive decline present in aging.

Citations

Dec 13, 2019·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Jennifer L RobinsonZbigniew J Pietrzkowski
Feb 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giorgio D'AndreaFelice Tirone
Feb 25, 2020·Food & Function·Milda KeršienėDaiva Leskauskaitė
May 14, 2020·Nutrients·Assylzhan YessenkyzyTalgat Nurgozhin
Aug 6, 2019·Frontiers in Cell and Developmental Biology·Sabrina PicocciGianfranco Gennarini
Jun 21, 2019·Molecular Nutrition & Food Research·Dorrain Yanwen LowClaudine Manach
Oct 9, 2020·The British Journal of Nutrition·Leticia GoniEstefanía Toledo
Dec 19, 2020·IBRO Reports·Daniel Silva MoraesSérgio Henrique Sousa Santos
Mar 31, 2021·Brain Plasticity·Daniel Joseph Lamport, Claire Michelle Williams
Jul 11, 2021·Neuroscience and Biobehavioral Reviews·Giuseppe AnnunziataSeyed Mohammad Nabavi

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