Dietary Polysaccharide from Enteromorpha Clathrata Modulates Gut Microbiota and Promotes the Growth of Akkermansia muciniphila , Bifidobacterium spp. and Lactobacillus spp

Marine Drugs
Qingsen ShangGuangli Yu

Abstract

Recently, accumulating evidence has suggested that Enteromorpha clathrata polysaccharide (ECP) could contribute to the treatment of diseases. However, as a promising candidate for marine drug development, although ECP has been extensively studied, less consideration has been given to exploring its effect on gut microbiota. In this light, given the critical role of gut microbiota in health and disease, we investigated here the effect of ECP on gut microbiota using 16S rRNA high-throughput sequencing. As revealed by bioinformatic analyses, ECP considerably changed the structure of the gut microbiota and significantly promoted the growth of probiotic bacteria in C57BL/6J mice. However, interestingly, ECP exerted different effects on male and female microbiota. In females, ECP increased the abundances of Bifidobacterium spp. and Akkermansia muciniphila, a next-generation probiotic bacterium, whereas in males, ECP increased the population of Lactobacillus spp. Moreover, by shaping a more balanced structure of the microbiota, ECP remarkably reduced the antigen load from the gut in females. Altogether, our study demonstrates for the first time a prebiotic effect of ECP on gut microbiota and forms the basis for the development of ECP a...Continue Reading

References

Feb 13, 2001·Journal of Biotechnology·M SaarelaT Mattila-Sandholm
Apr 25, 2006·Journal of Clinical Gastroenterology·Julia M W WongDavid J A Jenkins
Jan 11, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M D KlokM L Drent
Feb 2, 2008·Nature Reviews. Drug Discovery·Wei JiaJeremy K Nicholson
Apr 9, 2008·Peptides·João-Bruno Soares, Adelino F Leite-Moreira
Oct 30, 2009·International Journal of Molecular Sciences·Huey-Shi LyeMin-Tze Liong
Nov 4, 2010·Nature Reviews. Gastroenterology & Hepatology·Ahmed Abu-Shanab, Eamonn M M Quigley
May 14, 2011·Marine Drugs·Guangling JiaoH Stephen Ewart
Sep 13, 2011·International Journal of Biological Macromolecules·Jin-Kyung KimSang Guan You
Oct 4, 2011·Acta Diabetologica·Rémy BurcelinJacques Amar
Mar 23, 2012·The ISME Journal·Clara Belzer, Willem M de Vos
Jun 8, 2012·Science·Jeremy K NicholsonSven Pettersson
Feb 26, 2013·Nature Reviews. Microbiology·Felix Sommer, Fredrik Bäckhed
Apr 2, 2013·International Journal of Biological Macromolecules·Zhihong TangSong Qin
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
Jul 19, 2013·Nature Communications·Chenhong ZhangLiping Zhao
Sep 26, 2013·International Journal of Biological Macromolecules·Zhaolin TengYan Zhou
Dec 18, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T R AbrahamssonM C Jenmalm
Apr 29, 2014·Frontiers in Neurology·James M HillWalter J Lukiw
Sep 10, 2014·Nature Reviews. Microbiology·Petra LouisHarry J Flint
Apr 1, 2015·Nature Reviews. Gastroenterology & Hepatology·Laure B BindelsJens Walter
Apr 29, 2015·European Journal of Pharmacology·Jakub BukowczanArtur Dembinski
May 15, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C S ByrneG Frost
Jul 1, 2015·Current Opinion in Nephrology and Hypertension·Pedro A Jose, Dominic Raj
Aug 12, 2015·Nature Reviews. Endocrinology·Emanuel E CanforaEllen E Blaak
Oct 13, 2015·World Journal of Gastroenterology : WJG·Agata Mulak, Bruno Bonaz
Dec 30, 2015·BioMed Research International·Aleksandra MatuszykArtur Dembiński
Jan 15, 2016·Nature·Erica D SonnenburgJustin L Sonnenburg
Jan 23, 2016·Oxidative Medicine and Cellular Longevity·Aleksandra MatuszykArtur Dembiński
Feb 2, 2016·Marine Drugs·Maria Filomena de Jesus RaposoRui Manuel Santos Costa de Morais
Feb 16, 2016·Microbial Pathogenesis·Muriel DerrienWillem M de Vos
Mar 1, 2016·Frontiers in Microbiology·David Ríos-CoviánNuria Salazar
May 11, 2016·International Journal of Biological Macromolecules·Qingsen ShangGuangli Yu
Jun 19, 2016·International Journal of Biological Macromolecules·Qing KongChaoyu Jiang

❮ Previous
Next ❯

Citations

Feb 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aroa Lopez-SantamarinaAlberto Cepeda
Nov 22, 2019·International Journal of Biological Macromolecules·Baiyuan LiYeshi Yin
Jun 15, 2021·Applied Microbiology and Biotechnology·Tatsuro Hagi, Clara Belzer
Aug 18, 2021·Food Research International·Yuezhen OuyangChao Zhao

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA
ELISA

Software Mentioned

LEfSe
R Foundation for Statistical Computing
GraphPad Prism
R
USEARCH
Mothur

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.