Dietary Potential Renal Acid Load and Risk of Albuminuria and Reduced Kidney Function in the Jackson Heart Study

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
Tanushree BanerjeeNeil R Powe

Abstract

Diets high in sulfur-rich protein and low in fruit and vegetables affect human acid-base balance adversely and may have a harmful effect on progression of chronic kidney disease (CKD). Little is known about the relationship of participant characteristics, dietary acid load (DAL), and kidney injury in African-Americans with high risk of CKD progression. We examined the association of DAL with CKD in 3,257 African-Americans aged >20 years in Jackson Heart Study. DAL was measured with nutrient intakes assessed with a food frequency questionnaire, using a model described by Remer and Manz. We tested associations of participant characteristics with DAL using median regression, and associations of DAL with albuminuria (>17 mg/g for men, >25 mg/g for women), reduced kidney function (eGFR <60 mL/minute/1.73 m2), or CKD defined as albuminuria or reduced kidney function using logistic regression. We further explored whether endothelin and aldosterone production in participants with hypertension mediated risk of albuminuria or reduced kidney function due to the intake of an acid-inducing diet. Younger adults, men, and those with higher body mass index had higher DAL. Higher DAL, compared with lower, was associated with greater odds of red...Continue Reading

Citations

Jun 7, 2019·Nutrients·Aleix CasesEmilio Gonzalez-Parra
Jun 13, 2020·Nature Reviews. Nephrology·Juan J CarreroDenis Fouque
Sep 26, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Katrina E BachKatrina L Campbell
Sep 3, 2020·European Journal of Clinical Nutrition·Michelle LópezGilmary Marcano
Nov 12, 2020·Nutrients·Joanna OstrowskaDorota Szostak-Węgierek
Feb 13, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Laetitia KoppeDenis Fouque
Mar 21, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Donald E Wesson

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