Dietary prevention of Helicobacter pylori-associated gastric cancer with kimchi

Oncotarget
Migyeong JeongKi-Baik Hahm

Abstract

To prove whether dietary intervention can prevent Helicobacter pylori-induced atrophic gastritis and gastric cancer, we developed cancer preventive kimchi (cpKimchi) through special recipe and administered to chronic H. pylori-initiated, high salt diet-promoted, gastric tumorigenesis mice model. H. pylori-infected C57BL/6 mice were administered with cpKimchi mixed in drinking water up to 36 weeks. Gross and pathological gastric lesions were evaluated after 24 and 36 weeks, respectively and explored underlying molecular changes to explain efficacies. Cancer preventive actions of anti-inflammation and anti-mutagenesis were compared between standard recipe kimchi (sKimchi) and special recipe cpKimchi in in vitro H. pylori-infected cell model. The erythematous and nodular changes, mucosal ulcerative and erosive lesions in the stomach were noted at 24th weeks, but cpKimchi administration significantly ameliorated. After 36th weeks, scattered nodular masses, some ulcers, and thin nodular gastric mucosa were noted in H. pylori-infected mice, whereas these gross lesions were significantly attenuated in cpKimchi group. On molecular analysis, significant expressions of COX-2 and IL-6, activated NF-κB and STAT3, increased apoptosis, and m...Continue Reading

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Citations

Sep 25, 2017·Nutrition and Cancer·Syed Faisal ZaidiToshiro Sugiyama
Oct 9, 2019·Journal of Clinical Biochemistry and Nutrition·Jeong Min AnKi Baik Hahm
Dec 23, 2015·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sang Hwan LeeKi Baik Hahm
Jul 15, 2017·Expert Review of Gastroenterology & Hepatology·Yong Seok KimKi Baik Hahm
Dec 10, 2020·Journal of Clinical Biochemistry and Nutrition·Young-Min HanKi Baik Hahm
Dec 6, 2020·Antioxidants·Jose D Puentes-PardoJosefa León
May 25, 2021·Journal of Clinical Biochemistry and Nutrition·Jong Min ParkKi Baik Hahm
Jul 27, 2021·Scandinavian Journal of Gastroenterology·Jun-Yan JiangMao-Xia Liu

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Methods Mentioned

BETA
ELISA
MDA
electrophoresis

Software Mentioned

GraphPad Prism
SPSS

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