PMID: 2498029Jan 1, 1989Paper

Dietary propylthiouracil and 17 beta-estradiol benzoate implant effects on liver carbohydrate and lipid metabolism in chicks

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
R W RosebroughN C Steele

Abstract

1. Forty-eight chicks (21 days old) were implanted (+/- 50 mg 17-beta estradiol; EBI) and fed diets containing +/- 0.1% propylthiouracil (PTU) for 7 days to determine the role of gonadal hormones in the regulation of energy metabolism in the hypothyroid chick. 2. In vitro lipogenesis (IVL) and glucose production (NGP) were measured in liver explants. 3. Liver glycogen (GLY) metabolism was studied in particulate fractions (50,000 x g) of liver. 4. Glycogen synthetase activity (GLYSYN) was assayed in the presence of glucose-6-phosphate (G-6P; 0, 0.15 and 10 mM) to determine activation states. 5. PTU and EBI increased (P less than 0.05) both GLY concentration and GLYSYN activity in chicks but, did not increase G-6P activity ratios or the in vitro activation of GLYSYN. 6. Both PTU and EBI increased (P less than 0.05) IVL and NGP. 7. Estradiol magnifies the effects of PTU in chicks suggesting an interaction between thyroid status and gonadal function.

References

Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R W Rosebrough, N C Steele
Jul 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E R KühnE Decuypere
Apr 1, 1974·The Journal of Endocrinology·D Balnave, J Pearce
Feb 16, 1972·Biochemical and Biophysical Research Communications·J B Allred, K L Roehrig
Mar 1, 1972·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K L RahejaJ Tepperman
Feb 1, 1971·General and Comparative Endocrinology·K L Raheja, J G Snedecor
Feb 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K L RahejaS E Fineberg
Apr 1, 1983·Poultry Science·J P McMurtryN C Steele

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Citations

Jan 1, 1990·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R W Rosebrough, M F Von Vleck
Jan 1, 1994·Medicine and War·N A Coulter
Jan 1, 1992·Medicine and War·N A Coulter
Dec 16, 1998·The British Journal of Nutrition·S SalminenI Rowland

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