Apr 1, 1984

Dietary protein: a trigger of insulin-dependent diabetes in the BB rat?

Diabetologia
R B Elliott, J M Martin

Abstract

Animals from a colony of spontaneously diabetic insulin-dependent BB rats were fed from weaning with semi-synthetic diets in which natural proteins were replaced by l-amino acids with or without the addition of either milk or wheat proteins. The normal 50% incidence of diabetes in the colony was reduced to 15% in rats fed the basic semi-synthetic diet, while it was 35% and 52% when supplemented with gluten or milk, respectively. Thus, dietary factors might precipitate the expression of the disease.

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Mentioned in this Paper

Amino Acids, I.V. solution additive
August Rats
Gluten
Streptozotocin Diabetes
Novolin
Diabetes Mellitus, Insulin-Dependent
Rats, Inbred BB
Dietary Proteins
Immune Response TO Synthetic POLYPEPTIDE--IRGAT
Antifibrinolytic amino acids

About this Paper

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