Dietary protein enterocolitis

Current Allergy Reports
A M Lake

Abstract

Dietary protein enterocolitis generally presents in the 1st year of life with diarrhea, emesis, and irritability. When there is a delay in diagnosis, persistent exposure to the offending dietary antigen leads to increasing enteric inflammation manifesting as bloody diarrhea, anemia, dehydration, and failure to sustain normal patterns of weight gain and growth. The extent of enteric inflammation may be limited to mild proctitis, pancolitis, or true enterocolitis with esophagitis, gastritis, enteropathy, and colitis. The offending antigen is usually cow's milk protein or soy protein. A significant number of the infants are exclusively breast fed, especially those with proctitis. In older children, a wide variety of dietary proteins have been implicated. The inconsistency between allergists and gastroenterologists in the clinical definition of the syndrome remains a significant problem. To the allergist, the definition is based on clinical criteria, allergy testing, and response to double-blind food challenge, whereas to the gastroenterologist, it is defined by histologic criteria and the response of clinical and histologic manifestations to elimination diets. To further complicate the issue, European studies have emphasized the a...Continue Reading

References

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Citations

Apr 7, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·UNKNOWN American College of Allergy, Asthma, & Immunology
May 21, 2011·Expert Review of Clinical Immunology·Jean-Christoph Caubet, Anna Nowak-Węgrzyn
Jun 23, 2012·International Immunopharmacology·Li-Li LiuTian-Ci Yang
May 6, 2004·Current Opinion in Allergy and Clinical Immunology·Ralf G Heine
May 1, 2012·Physical Review Letters·Raúl García-PatrónNicolas J Cerf
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Oct 4, 2006·The Medical Journal of Australia·Katrina J AllenRalf G Heine
Nov 22, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Puja Sood RajaniKirsi M Järvinen

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