PMID: 7513952Apr 1, 1994Paper

Dietary protein-induced renal growth: correlation between renal IGF-I synthesis and hyperplasia

The American Journal of Physiology
E Chin, C Bondy

Abstract

Insulin-like growth factor I (IGF-I) and IGF binding protein 1 (IGFBP-1) mRNAs are colocalized in the medullary thick ascending limb (MTAL) of the rat nephron, a segment that undergoes selective growth in response to elevated dietary protein. In the present study, rats were fed isocaloric diets containing variable protein content (6-40%) for 1-7 days, and changes in fractional renal weight, MTAL length, and regional DNA synthesis were assayed and compared with local changes in IGF-I/IGFBP-1 mRNAs, as determined by quantitative in situ hybridization. Rats switched to high-protein diets demonstrated increased IGF-I and decreased IGFBP-1 mRNA levels in MTALs, whereas those switched to low protein showed inverse changes. The increase in renal IGF-I mRNA was maximal at 2 days and was closely paralleled by significant increases in fractional renal weight, DNA synthesis, and MTAL length. Similar changes were seen in vasopressin-deficient Brattleboro and growth hormone (GH)-deficient dwarf rats in response to high-protein diets, suggesting that the effects of dietary protein in this model are not mediated by vasopressin or GH. The close spatial and temporal correlation between changes in renal IGF-I expression and changes in regional g...Continue Reading

References

Oct 1, 1992·Diabetes/metabolism Reviews·L A Bach, M M Rechler
Oct 1, 1988·The Journal of Endocrinology·H M CharltonB A Bloch
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Citations

Apr 3, 1999·Medicine and Science in Sports and Exercise·R HaywardC M Schneider
Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Allan FlyvbjergRuth Rasch
May 28, 2005·Cell Biochemistry and Function·Tania C Pithon-CuriSonia Q Doi
Jan 3, 2001·Kidney International·H M Aukema, I Housini
Apr 23, 2002·Kidney International·Bieke F SchrijversAllan Flyvbjerg
May 14, 1998·The Journal of Laboratory and Clinical Medicine·B M MurrayM Schoenl
Nov 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Vesna Cingel-RistićStenvert L S Drop
Sep 18, 2002·Kidney International·Johan W van NeckAllan Flyvbjerg
Aug 1, 2009·Kidney International·Rosemary Thomas, Frederick J Kaskel

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