Dietary protein intake affects expression of genes for lipid metabolism in porcine skeletal muscle in a genotype-dependent manner

The British Journal of Nutrition
Yingying LiuGuoyao Wu

Abstract

Skeletal muscle is a major site for the oxidation of fatty acids (FA) in mammals, including humans. Using a swine model, we tested the hypothesis that dietary protein intake regulates the expression of key genes for lipid metabolism in skeletal muscle. A total of ninety-six barrows (forty-eight pure-bred Bama mini-pigs (fatty genotype) and forty-eight Landrace pigs (lean genotype)) were fed from 5 weeks of age to market weight. Pigs of fatty or lean genotype were randomly assigned to one of two dietary treatments (low- or adequate-protein diet), with twenty-four individually fed pigs per treatment. Our data showed that dietary protein levels affected the expression of genes involved in the anabolism and catabolism of lipids in the longissimus dorsi and biceps femoris muscles in a genotype-dependent manner. Specifically, Bama mini-pigs had more intramuscular fat, SFA and MUFA, as well as elevated mRNA expression levels of lipogenic genes, compared with Landrace pigs. In contrast, Bama mini-pigs had lower mRNA expression levels of lipolytic genes than Landrace pigs fed an adequate-protein diet in the growing phase. These data are consistent with higher white-fat deposition in Bama mini-pigs than in Landrace pigs. In conclusion, a...Continue Reading

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Aug 16, 2014·Annals of the New York Academy of Sciences·Guoyao WuAnna E Thalacker-Mercer

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Citations

Jun 2, 2018·PloS One·Christian HellmuthFranca F Kirchberg
Nov 28, 2018·Journal of the Science of Food and Agriculture·Kang XuYulong Yin
Sep 4, 2019·Journal of Animal Physiology and Animal Nutrition·Yingying LiuYulong Yin
Jul 24, 2018·Journal of Animal Science and Biotechnology·Yuming WangShiyan Qiao

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