PMID: 6168287Jun 26, 1981Paper

Dietary regulation of pancreatic protein synthesis. I. Rapid and specific modulation of enzyme synthesis by changes in dietary composition

Biochimica Et Biophysica Acta
J C Dagorn, R G Lahaie

Abstract

Dietary adaptation of pancreatic protein synthesis and of pancreatic enzyme concentration, was studied over the first 24 h of exposure to a new diet. Rats were adapted to a carbohydrate-rich (G) or to a protein-rich diet (P) and were switched to the opposite regime after a 15 h fast. The evolution of the relative rate of synthesis of amylase, chymotrypsinogen and trypsinogen and of the pancreatic concentration of amylase and chymotrypsinogen were followed. Fasting caused important modifications in the relative rate of synthesis of the three enzymes in rats adapted to a P diet. Adaptative changes in the relative rate of synthesis of amylase, chymotrypsinogen and trypsinogen were seen within 2 h after the beginning of refeeding. These changes were followed by corresponding adaptative modifications in pancreatic contents 4 h after the beginning of refeeding. After 24 h of refeeding, significant adaptative changes had occurred in both the relative rates of synthesis and in enzyme concentrations. Thus exocrine pancreatic protein synthesis can be modulated as early as 2 h after refeeding and this modulation is followed by adaptative changes in pancreatic enzyme content.

References

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Citations

Apr 18, 1998·Biochimica Et Biophysica Acta·M ApteJ Wilson
Jan 1, 1989·Nutrition Research Reviews·T CorringE F Lhoste
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·P MalfertheinerM Büchler
Mar 1, 1986·Biochimie·J C Dagorn
Mar 15, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·J HellerP D Hardt
Mar 1, 1995·Gastroenterology·M E MailliardG E Mann
Mar 29, 1985·Biochemical and Biophysical Research Communications·D GiorgiJ C Dagorn
Jun 22, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·H HaraT Hira
Jun 2, 1986·Klinische Wochenschrift·J Mössner, W Fischbach
Sep 1, 2004·Experimental Biology and Medicine·Hiroshi Hara, Hiromichi Shiota
Sep 9, 1992·Biochimica Et Biophysica Acta·P S Perkins, S J Pandol
Nov 22, 1988·Biochimica Et Biophysica Acta·M MuñozG E Mann
Feb 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·J L IovannaE L Calvo

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