Mar 12, 1982

Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence

Science
R Weindruch, R L Walford

Abstract

Lifelong dietary restriction beginning at 3 to 6 weeks of age in rodents is known to decelerate the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many spontaneous cancers. Little is known about the effects of dietary restriction started in middle age. In the experiments now reported the food intake of 12- to 13-month-old mice of two long-lived strains was restricted by using nutrient-enriched diets in accordance with the concept of "undernutrition without malnutrition." The mice on the restricted diet averaged 10 to 20 percent increases in mean and maximum survival times compared to the control mice. Spontaneous lymphoma was inhibited by the food restriction.

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Mentioned in this Paper

Pathological Fracture
Diet
Energy Intake
Neoplasms
Senility
Eating
Malnutrition
Malignant Neoplasms
Age Factors
Rodent

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