PMID: 8613897Apr 1, 1996Paper

Dietary restriction induces biochemical and morphometric changes in the small intestine of nursing piglets

The Journal of Nutrition
M C NúñezA Gil

Abstract

The purpose of this study was to evaluate the biochemical and morphometric changes in the small intestine of nursing piglets caused by 60% dietary restriction, and to ascertain whether this model reproduces the intestinal alterations caused by malnutrition in human infants. Piglets subjected to dietary restriction had significantly lower levels of mucosal DNA and protein, and significantly reduced segmental disaccharidase and leucine aminopeptidase activities compared with age-matched, freely fed controls. However, greater disaccharidase-specific activities were observed in duodenum and jejunum of diet restricted piglets compared with controls. Other findings included significantly lower thickness of the mucose, villous height and width, and villous surface area, a significantly lower number of goblet cells, and significantly greater mucosal crypt depth, intraepithelial leucocyte number, and infiltrated cells per area of lamina propria. The model reproduces most of the biochemical and morphometric changes observed in the small intestine of young human infants with chronic diarrhea and malnutrition, and may be useful in further investigations of the biochemical and molecular mechanisms of intestinal alterations caused by primary...Continue Reading

Citations

Apr 15, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Sandra Lúcia SchulerLúcia de Noronha
May 11, 2017·Journal of Pediatric Gastroenterology and Nutrition·Suzanna AttiaRobert H J Bandsma
Nov 5, 2005·British Poultry Science·B Maneewan, K Yamauchi
May 17, 2007·Acta Cirúrgica Brasileira·Diana Borges Dock-NascimentoJosé Eduardo de Aguilar-Nascimento
Dec 5, 2019·Animals : an Open Access Journal From MDPI·Silvia Clotilde ModinaAlessia Di Giancamillo
Oct 9, 2007·The British Journal of Nutrition·Jose María VieitesAntonio Suárez
Jul 17, 2009·The Journal of Nutrition·Hiroyuki ItoTatsuya Morita
Jul 1, 2011·Annals of Nutrition & Metabolism·Willemijn E CorpeleijnJohannes B van Goudoever
Jan 16, 2007·The British Journal of Nutrition·Lucile MontagneBernard Sève
Dec 28, 2019·Journal of Animal Physiology and Animal Nutrition·Hongbo YiLi Wang
Jan 11, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Takamitsu TsukaharaKazunari Ushida
Dec 1, 2009·Archives of Animal Nutrition·Florence Omobola OpapejuCharles Martin Nyachoti
Jan 8, 2020·PloS One·Emma T HelmNicholas K Gabler
Jul 7, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S Dunel-ErbY Le Maho
Dec 19, 2003·Micron : the International Research and Review Journal for Microscopy·Caroline HaboldJean-Hervé Lignot
Aug 11, 2010·Mitochondrion·Francisca M SantandreuPilar Roca

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