Dietary restriction protects against chronic-ethanol-induced changes in exploratory behavior in Wistar rats

Brain Research
Lucas S N M PintoAngela M Ribeiro

Abstract

Chronic ethanol intake causes various types of neural damage and behavioral impairments, probably acting through oxidative stress and excitotoxicity, while dietary restriction is considered by some authors to protect the central nervous system from these kinds of damage. In the present study, a factorial experimental design was used to investigate the effects of chronic ethanol and dietary restriction treatments, associated or not, on Wistar rats' exploratory behavior, spatial memory aspects and cortical and hippocampal acetylcholinesterase (AChE) activity. Dietary restriction lasted for the whole experiment, while ethanol treatment lasted for only 3 weeks. Despite the short ethanol treatment duration, for two behavior categories assessed, moving and rearing, an interaction was observed between the effects of chronic ethanol and dietary restriction. There were no significant differences in AChE activities among the groups. Cerebellar neural nitric oxide synthase (nNOs) activity was measured as a first step to assess oxidative stress. Dietary restriction significantly reduced NO formation. The present results indicate that dietary restriction might exert a protective effect against chronic-ethanol-induced changes in exploratory ...Continue Reading

References

Jun 1, 1992·Alcoholism, Clinical and Experimental Research·F E Lancaster
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Jan 1, 1987·Journal of Gerontology·D K IngramR L Walford
May 1, 1984·Journal of Neuroscience Methods·R Morris
Jul 1, 1995·Brain Research. Cognitive Brain Research·S J SaraA Hervé
Oct 20, 1994·Mechanisms of Ageing and Development·R S SohalH Lal
Jan 1, 1996·Bulletin of the History of Medicine·W Anderson
Jan 1, 1997·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·M NaassilaM Daoust
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·T HarkanyC Nyakas
Jan 14, 1998·Alcohol·D DiBattista, D Joachim
Apr 17, 1998·Australian and New Zealand Journal of Medicine·A J DavisS Milliken
May 26, 1998·Journal of Neuropathology and Experimental Neurology·C Harper
Jun 19, 1998·Pharmacology, Biochemistry, and Behavior·S R PereiraA M Ribeiro
Jul 17, 1998·Alcohol·M L Adams, T J Cicero
Jul 29, 1998·Neuroscience·C M ThielR K Schwarting
Dec 9, 1998·Journal of Biomedical Science·G Tsai
May 18, 1999·Life Sciences·M IkedaS Murota
Oct 19, 1999·Brain Research. Brain Research Reviews·F TorreillesJ Torreilles
Jun 29, 2000·Neurochemistry International·P R DoddP A Wilce
Jul 13, 2000·Brain Research. Molecular Brain Research·K Eckles-SmithM D Browning
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·N Schweighofer, G Ferriol
May 25, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·P PokkM Väli
Aug 22, 2002·The International Journal of Neuroscience·Semir OzdemirGülay Hacioğlu
Nov 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aiguo WuYugu Liu
Dec 10, 2002·Mechanisms of Ageing and Development·Hyon Jeen KimHae Young Chung
Dec 25, 2002·European Journal of Pharmacology·Anbrin MasoodArunabha Ray
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Jesper MogensenErling T Mellerup

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Citations

Sep 22, 2011·Neuroscience Bulletin·Elisabetta Biasi
Jul 26, 2011·Toxicology Mechanisms and Methods·Julio RubioGustavo F Gonzales
Sep 2, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Ketren Carvalho GomesFabiano Mendes de Cordova

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