Dietary restriction suppresses inflammation and delays the onset of stroke in stroke-prone spontaneously hypertensive rats

Biochemical and Biophysical Research Communications
Tsuyoshi Chiba, Osamu Ezaki

Abstract

Subjects with high blood levels of inflammatory markers and patients with chronic inflammatory disorders are at high risk for stroke. Dietary restriction (DR) suppresses systemic inflammation to deter age-related chronic diseases. To examine whether DR delays the onset of stroke, 10-week-old stroke-prone spontaneously hypertensive rats (SHRSP) were assigned to either a control (ad libitum) or DR (50% diet of control) group, and day of stroke onset and lifespan were observed. DR markedly delayed the onset of stroke in SHRSP compared to control without affecting blood pressure. Day of stroke onset (median) in the control group was 34days, whereas it was 70days in the DR group. After 2weeks of DR and before the onset of stroke, plasma levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and monocyte chemoattractant protein-1 (MCP-1) and their mRNA expression levels in adipose tissue were significantly lower in the DR rats than in the control rats. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) mRNA expression levels in cerebrovascular endothelial cells (CVECs), and macrophage infiltration into brain were lower in the DR rats than in the control rats. IL-1beta a...Continue Reading

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Citations

Sep 14, 2011·Experimental & Translational Stroke Medicine·Silvia ManzaneroThiruma V Arumugam
Feb 23, 2013·Mediators of Inflammation·Tsuyoshi Chiba, Keizo Umegaki
Feb 15, 2014·TheScientificWorldJournal·Xin-Fang LeongSrijit Das
Jun 7, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ebrahim RajabAmer Kamal
Jul 25, 2015·Clinical and Experimental Hypertension : CHE·Seyed Khosrow TayebatiFrancesco Amenta
Aug 16, 2011·Molecular Aspects of Medicine·John R Speakman, Sharon E Mitchell
Feb 28, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ai-Jun LiuDing-Feng Su
Oct 25, 2012·Journal of Neurochemistry·Claire L GibsonSean P Murphy
Nov 27, 2015·Molecular Genetics and Genomics : MGG·Seung-Soo KimCheol-Koo Lee
Apr 5, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Antonina CangemiAntonio Russo
Jan 18, 2013·Mediators of Inflammation·Tsuyoshi ChibaTakao Satou
Feb 5, 2013·Experimental Gerontology·Lauren T Robertson, James R Mitchell
Dec 14, 2011·Stroke; a Journal of Cerebral Circulation·Tsuyoshi ChibaOsamu Ezaki
Mar 4, 2020·Nutrients·Maria Vittoria Micioni Di BonaventuraDaniele Tomassoni
Apr 14, 2015·Expert Review of Neurotherapeutics·Tomasz Dziedzic
Jul 9, 2020·Metabolic Brain Disease·Sina MojaverrostamiIraj Ragerdi Kashani

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