Dietary rice bran promotes resistance to Salmonella enterica serovar Typhimurium colonization in mice.

BMC Microbiology
Ajay KumarElizabeth P Ryan

Abstract

Dietary rice bran consists of many bioactive components with disease fighting properties; including the capacity to modulate the gut microbiota. Studies point to the important roles of the gut microbiota and the mucosal epithelium in the establishment of protection against enteric pathogens, such as Salmonella. The ability of rice bran to reduce the susceptibility of mice to a Salmonella infection has not been previously investigated. Therefore, we hypothesized that the incorporation of rice bran into the diet would inhibit the colonization of Salmonella in mice through the induction of protective mucosal responses. Mice were fed diets containing 0%, 10% and 20% rice bran for one week prior to being orally infected with Salmonella enterica serovar Typhimurium. We found that mice consuming the 10 and 20% rice bran diets exhibited a reduction in Salmonella fecal shedding for up to nine days post-infection as compared to control diet fed animals (p < 0.05). In addition, we observed decreased concentrations of the pro-inflammatory cytokines, TNF-alpha, IFN-gamma, and IL-12 (p < 0.05) as well as increased colonization of native Lactobacillus spp. in rice bran fed mice (p < 0.05). Furthermore, in vitro experiments revealed the abilit...Continue Reading

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Citations

Sep 1, 2015·BMC Complementary and Alternative Medicine·Ana M SahagúnMatilde Sierra
Feb 11, 2014·Journal of Immunological Methods·Andrew W GoodyearElizabeth P Ryan
Nov 1, 2017·Scientific Reports·Hasinika K A H GamageIan T Paulsen
Sep 26, 2017·Critical Reviews in Food Science and Nutrition·Nevin ŞanlierAybüke Ceyhun Sezgin
May 17, 2019·PloS One·Luke A SchwerdtfegerStuart A Tobet
May 21, 2019·International Journal of Food Sciences and Nutrition·Michael D WirthJames R Hébert
Jun 16, 2017·Annual Review of Microbiology·Brittany B Lewis, Eric G Pamer
Dec 5, 2019·Animals : an Open Access Journal From MDPI·Huan WangRuihua Huang
Oct 18, 2019·Journal of Nutritional Science and Vitaminology·Naomi K Fukagawa, Lewis H Ziska
May 18, 2019·The American Journal of Pathology·Joseph M Pickard, Gabriel Núñez

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

FlowJo
Summit

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