Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats.

Lipids in Health and Disease
Bei ZhangYu-Ming Wang

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease in industrialized countries. The present study was undertaken to explore the preventive effect of dietary sea cucumber cerebroside (SCC) extracted from Acaudina molpadioides in fatty liver rats. Male Wistar rats were randomly divided into four groups including normal control group, NAFLD model group, and two SCC-treated groups with SCC at 0.006% and 0.03% respectively. The fatty liver model was established by administration of 1% orotic acid (OA) to the rats. After 10d, serum and hepatic lipid levels were detected. And the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were also determined. Besides, to gain the potential mechanism, the changes of key enzymes and gene expressions related to the hepatic lipid metabolism were measured. Dietary SCC at the level of 0.006% and 0.03% ameliorated the hepatic lipid accumulation in fatty liver rats. SCC administration elevated the serum triglyceride (TG) level and the ALT, AST activities in OA-fed rats. The activities of hepatic lipogenic enzymes including fatty acid synthase (FAS), malic enzyme (ME) and glucose-6-phosphatedehydrogenase (G6PDH) were inhibited by SCC treatme...Continue Reading

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Citations

Jul 15, 2015·Nutrients·Alina Adriana IvanescuAlfredo García-Layana
Feb 6, 2017·Molecular Nutrition & Food Research·Yingdong Zhu, Shengmin Sang
Oct 28, 2019·Canadian Journal of Physiology and Pharmacology·Dionysius SubaliHee Eun Kang
Mar 27, 2020·Critical Reviews in Food Science and Nutrition·Xiaoxu WangChanghu Xue

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