Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats.

The British Journal of Nutrition
Jan FrankA Kamal-Eldin

Abstract

Secoisolariciresinol diglucoside (SDG) is an important dietary lignan that is found at very high levels in flaxseed (1-4 %, w/w). Flaxseed lignans have received much research interest in recent years because of reported phyto-oestrogenic, anticarcinogenic, and anti-atherogenic effects. Previously, flaxseed feeding has been shown to decrease vitamin E concentrations in rats despite the antioxidant potential of SDG in vitro. Sesamin, a sesame lignan, on the other hand has been shown to increase vitamin E concentrations in rats. The aim of the present study was to investigate the effect of dietary SDG and its oligomers on vitamin E and cholesterol concentrations in rats. SDG was extracted from defatted flaxseed flour with a dioxane-ethanol mixture and purified by silica column chromatography. The major oligomers with 3-hydroxy-3-methyl glutaric acid, containing a high ratio of SDG to p-coumaric and ferulic acid glucosides, were purified from the extracts by reversed-phase liquid chromatography. When fed to rats at 0.1 % in the diet for 27 d, both SDG and its oligomers had no effect on animal performance but caused an increase in liver cholesterol and a 2-fold reduction in the levels of alpha- and gamma-tocopherols in rat plasma an...Continue Reading

References

Oct 1, 1978·Analytical Biochemistry·A Hara, N S Radin
Jan 1, 1985·The Journal of Applied Bacteriology·S P BorrielloA M Lawson
Aug 1, 1994·Rapid Communications in Mass Spectrometry : RCM·M Bambagiotti-AlbertiA Raffaelli
Jan 1, 1996·Nutrition and Cancer·L U ThompsonH H Fong
Apr 4, 1998·The Journal of Nutrition·S E Rickard, L U Thompson
Mar 13, 1999·The American Journal of Clinical Nutrition·P D NesbittL U Thompson
Dec 20, 1999·Journal of Agricultural and Food Chemistry·E Jacobs, M Metzler
Dec 20, 1999·Journal of Agricultural and Food Chemistry·L P MeagherB W Li
Sep 20, 2000·Journal of Agricultural and Food Chemistry·A D Muir, N D Westcott
Nov 18, 2000·Analytical Biochemistry·J LigginsS A Bingham
Nov 23, 2000·Journal of Agricultural and Food Chemistry·P JohnssonP Aman
May 23, 2001·Free Radical Biology & Medicine·A GürbayF Hincal
May 9, 2002·The Journal of Biological Chemistry·Timothy J Sontag, Robert S Parker
Sep 25, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Heike B Niemeyer, Manfred Metzler
Nov 28, 2002·Journal of Agricultural and Food Chemistry·Jan FrankBengt Vessby
Feb 20, 2003·Journal of Agricultural and Food Chemistry·Tina SiciliaManfred Metzler
Mar 20, 2003·Journal of Agricultural and Food Chemistry·Nikolaos NenadisMaria Z Tsimidou

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Citations

Dec 15, 2007·Journal of Nutritional Science and Vitaminology·Kanae YamashitaRisto Santti
Jul 19, 2011·Ageing Research Reviews·Jan FrankGerald Rimbach
May 18, 2007·Reproduction in Domestic Animals = Zuchthygiene·C CastelliniF Galli
Jun 21, 2016·The Journal of Veterinary Medical Science·Jiasan ZhengHongbin Wang
Mar 22, 2007·The Journal of Nutrition·Ali A MoazzamiAfaf Kamal-Eldin
Sep 15, 2018·Current Diabetes Reviews·D E Barre, K A Mizier-Barre
Nov 19, 2020·Nutrients·Jorge SimónMaría Luz Martínez-Chantar

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