Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma

Cancer
Lin CaiZuo-Feng Zhang

Abstract

To the authors' knowledge, few studies have been conducted to date regarding dietary selenium and the potential gene-nutrient interactions with single-nucleotide polymorphisms (SNPs) in different pathways on the risk of esophageal cancer. The authors investigated the role of dietary selenium intake and its interplay with SNPs of the ALDH2 (glutamic acid [Glu] 487 lysine [Lys]) and the X-ray repair cross-complementing 1 (XRCC1) (arginine [Arg] 399 glutamine [Gln]) genes on the risk of esophageal squamous cell carcinoma (ESCC) in a population-based, case-control study in China. In total, 218 patients with ESCC and 415 healthy population control participants were interviewed. Dietary selenium intake was estimated from a food frequency questionnaire with 97 food items. ALDH2 and XRCC1 polymorphisms were detected with a polymerase chain reaction-restriction fragment length polymorphism assay. The adjusted odds ratio (OR) for the highest quintile of dietary selenium intake, compared with the lowest quintile of intake, was 0.48 (95% confidence interval [95% CI], 0.25-0.89), with a strong dose-response relation (P for trend, <.01). The ALDH2 Lys and XRCC1 Gln variant alleles were associated with an increased risk of ESCC with adjusted ...Continue Reading

References

Jan 1, 1984·Annual Review of Nutrition·G F Combs, S B Combs
Sep 1, 1983·Journal of Epidemiology and Community Health·B LloydB E Clayton
Apr 29, 1998·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·S J Díaz-Cano, S P Brady
Jul 27, 1999·International Journal of Cancer. Journal International Du Cancer·X CastellsaguéM J Quintana
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O W Brawley, H Parnes
Apr 11, 2001·Mutation Research·K El-Bayoumy
Jun 16, 2001·International Journal of Cancer. Journal International Du Cancer·J M LeeM T Wu
May 21, 2003·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Mohammad R Kafai, Vijay Ganji
Sep 18, 2003·Journal of the National Cancer Institute·Lawrence S EngelJoseph F Fraumeni
Sep 18, 2003·Journal of the National Cancer Institute·Philip R TaylorSteven D Mark
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Dec 20, 2003·Cancer Causes & Control : CCC·Ariana ZekaDavid Kriebel
May 13, 2004·Toxicology·Lynnette R FergusonNishi Karunasinghe
Jul 1, 2004·Cancer Detection and Prevention·Hong-Ping YuShun-Qing Xu
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Chien-Hung LeeMing-Tsang Wu
Feb 11, 2005·International Journal of Cancer. Journal International Du Cancer·Lori C SakodaKatherine A McGlynn
Apr 21, 2005·Journal of the National Cancer Institute·Rayjean J HungPaolo Boffetta
Apr 28, 2005·International Journal of Cancer. Journal International Du Cancer·Li-Na MuZuo-Feng Zhang
May 18, 2005·Cancer Detection and Prevention·Tianli Qu, Kanehisa Morimoto
Jun 9, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Werner GaravelloCarlo La Vecchia

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Citations

Sep 4, 2010·Antioxidants & Redox Signaling·Susan J Fairweather-TaitRachel Hurst
Jul 16, 2010·World Journal of Gastroenterology : WJG·Ying-Zhi ZhouJia Cui
Sep 2, 2010·World Journal of Gastroenterology : WJG·Shu-Juan YangChun-Xia Yang
Jan 21, 2016·Scientific Reports·Xianlei CaiFudi Wang
May 16, 2009·International Journal of Cancer. Journal International Du Cancer·Liping DaiYanping Wang
Aug 4, 2007·International Journal of Cancer. Journal International Du Cancer·Toru HiyamaKazuaki Chayama
Jul 29, 2011·International Journal of Cancer. Journal International Du Cancer·Akira YokoyamaKatsuya Maruyama
Dec 19, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·X Q ChenZ J Ma
Nov 17, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yao-Yuan HsiehFuu-Jen Tsai

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