PMID: 8945984Nov 1, 1996Paper

Dietary sodium effects on renin and angiotensinogen gene expression in preweanling WKY and SHR

The American Journal of Physiology
R F KirbyJ E Robillard

Abstract

The influence of altered dietary sodium on angiotensinogen and renin gene expression was examined in young normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Artificial rearing was used to increase or decrease dietary sodium intake during the preweanling period. In normally reared control animals, renal renin and liver angiotensinogen mRNA decreased between 6 and 30 postnatal days of age. In contrast, in the central nervous system, angiotensinogen mRNA increased between 6 and 30 days of age, and renin mRNA remained stable. Dietary sodium manipulation between postnatal days (PD) 6 and 18 significantly influenced renal renin gene expression, with low-sodium diet increasing renin mRNA on PD12 and PD18 and high-sodium diet decreasing renin mRNA on PD18. Liver angiotensinogen mRNA decreased for animals on either diet on PD12 and PD18. Brain angiotensinogen and renin mRNA were not affected by dietary sodium levels. There were no strain-related differences in the response to high and low dietary sodium. These results demonstrate that 1) the peripheral and central renin-angiotensin systems do not have a common ontogenetic pattern of development, 2) they are independently regulated in response to dietary sodium v...Continue Reading

Citations

Feb 6, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mariana Rosso MeloEduardo Colombari
May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D B Jennings, H J Lockett

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