Dietary soy-derived isoflavone phytoestrogens. Could they have a role in coronary heart disease prevention?

Biochemical Pharmacology
M J Tikkanen, H Adlercreutz

Abstract

Soy protein-containing foods are a rich source of isoflavone phytoestrogens, such as genistein and daidzein. There is great interest in these substances, as lower rates of chronic diseases, including coronary heart disease, have been associated with high dietary intake of soy-containing foods. Soy phytoestrogens bind weakly to estrogen receptors, and some bind more strongly to estrogen receptor-beta compared with estrogen receptor-alpha. A meta-analysis has indicated that isoflavone phytoestrogens lowered plasma cholesterol concentrations in subjects with initially elevated levels, but had little effect in subjects with normal cholesterol concentrations. These substances reportedly may also have beneficial effects on arterial endothelial function. In addition to these potentially antiatherogenic effects, many laboratories are investigating other possible mechanisms, including antioxidative and antiproliferative properties of these substances. We have shown that dietary supplementation with soy-derived isoflavones reduced the in vitro oxidation susceptibility of low-density lipoprotein (LDL). To further explore this phenomenon, we incorporated genistein and daidzein into LDL molecules in vitro with the aid of an artificial trans...Continue Reading

References

Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·R B HochbergJ M Larner
Dec 23, 1983·Science·L Janocko, R B Hochberg
Jul 1, 1995·Journal of Cardiovascular Pharmacology·W Abebe, D K Agrawal
Aug 3, 1995·The New England Journal of Medicine·J W AndersonM E Cook-Newell
Jun 1, 1995·The American Journal of Physiology·E M GouldR A Murphy
Aug 31, 1993·Biochemical and Biophysical Research Communications·Y FujioN Shibata
Jan 1, 1994·Nutrition and Cancer·M J MessinaS Barnes
Jun 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K ShimokadoJ Ogata
Oct 1, 1995·Environmental Health Perspectives·H Adlercreutz
Feb 1, 1996·Carcinogenesis·T T WangJ M Phang
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
Jan 1, 1997·Fertility and Sterility·E K HonoréT B Clarkson
Apr 1, 1997·Annals of Medicine·H Adlercreutz, W Mazur
Nov 14, 1997·Journal of Women's Health·T HolM W Draper
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M S AnthonyJ D Wagner
Jan 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·P J NestelM Abbey
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·M J TikkanenH Adlercreutz
Dec 16, 1998·The American Journal of Clinical Nutrition·M S AnthonyJ K Williams
Mar 30, 1999·Current Opinion in Lipidology·A Cassidy
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MäkeläP Häyry
Jan 1, 1995·Trends in Endocrinology and Metabolism : TEM·T B ClarksonC L Hughes

❮ Previous
Next ❯

Citations

Jun 10, 2004·World Journal of Gastroenterology : WJG·Hai-Bo ZhouQin Du
Feb 24, 2001·Drug Metabolism and Drug Interactions·S GoldwynH Wei
Oct 2, 2002·Acta Physiologica Scandinavica·M J TikkanenM Kaamanen
Nov 8, 2002·The Journal of Nutrition·Delia M BrownsonTom J Mabry
Jun 19, 2003·Nutrition Today·Mark Messina, Virginia Messina
Sep 2, 2003·The Journal of Nutrition·Xianglan ZhangWei Zheng
Apr 5, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Balu K ChackoRakesh P Patel
Jun 18, 2005·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Ritu AnejaRamesh Chandra
Mar 1, 2006·International Journal of Cancer. Journal International Du Cancer·Jane L LimerValerie Speirs
Jan 17, 2007·Menopause : the Journal of the North American Menopause Society·Robert BadeauTomi S Mikkola
Dec 1, 2006·International Journal of Food Sciences and Nutrition·Jeonghee SurhHoonjeong Kwon
May 9, 2007·Journal of Nutritional Science and Vitaminology·Takafumi MizushigeKiyoshi Ebihara
Jun 11, 2011·Menopause : the Journal of the North American Menopause Society·LeeCole L LegetteConnie M Weaver
Sep 8, 2011·Cell Biochemistry and Biophysics·Ren-Jie ZhouZhen-Zhou Yang
Jun 18, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Michaela Kopečná-ZapletalováEva Anzenbacherová
Sep 30, 2016·Journal of Cellular and Molecular Medicine·Yung-Chieh TsaiPao-Yun Cheng
Dec 21, 2000·Current Atherosclerosis Reports·C M HaslerD Wool
Sep 21, 2004·Annual Review of Plant Biology·Richard A Dixon
Aug 24, 2005·Archives of Pharmacal Research·Byung-Ju JeonHae-Soo Kwak
Sep 30, 2005·Nutrition Reviews·Adetayo O Omoni, Rotimi E Aluko
Apr 12, 2006·Menopause : the Journal of the North American Menopause Society·Riina M TörmäläTomi S Mikkola
Aug 25, 2012·The British Journal of Nutrition·A K JukantiR N Chibbar
Mar 22, 2014·Biomedical Reports·Qinglu WangPingping Zhang
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Brian S Cummings, Rick G Schnellmann
Aug 28, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·C R Sirtori
Feb 25, 2003·The Journal of Cardiovascular Nursing·Clare M Hasler
May 21, 2008·Journal of Pharmacological Sciences·Ji-Yeon YuYeo-Pyo Yun
Sep 3, 2009·Journal of Food Science·Karen GarciaWitoon Prinyawiwatkul
May 9, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter CelecDaniela Ostatníková
May 30, 2013·BMC Complementary and Alternative Medicine·Werner CordierVanessa Steenkamp
Jun 18, 2017·Journal of Nutritional Science·A N PancheS R Chandra
Feb 9, 2005·The American Journal of Clinical Nutrition·Siyan Zhan, Suzanne C Ho
Sep 15, 2009·The British Journal of Nutrition·Hsu-Fang ChouYi-Ju Chen
Jan 24, 2007·The Journal of Nutrition·Balu K ChackoRakesh P Patel
Nov 25, 2005·European Journal of Nutrition·I Rosier Olimpio Pereira, D Saes Parra Abdalla

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