PMID: 18203900Jan 22, 2008Paper

Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression

The Journal of Nutrition
Shanmugam NagarajanThomas M Badger

Abstract

Soy-based diets reportedly protect against the development of atherosclerosis; however, the underlying mechanism(s) for this protection remains unknown. In this report, the mechanism(s) contributing to the atheroprotective effects of a soy-based diet was addressed using the apolipoprotein E knockout (apoE-/-) mice fed soy protein isolate (SPI) associated with or without phytochemicals (SPI+ and SPI-, respectively) or casein (CAS). Reduced atherosclerotic lesions were observed in aortic sinus and enface analyses of the descending aorta in SPI+- or SPI(-)-fed apoE-/- mice compared with CAS-fed mice. SPI+-fed mice showed 20% fewer lesions compared with SPI(-)-fed mice. Plasma lipid profiles did not differ among the 3 groups, suggesting alternative mechanism(s) could have contributed to the atheroprotective effect of soy-based diets. Real-time quantitative PCR analyses of proximal aorta showed reduced expression of monocyte chemoattractant protein-1 (MCP-1), a monocyte chemokine, in mice fed both soy-based diets compared with the CAS-fed mice. These findings paralleled the reduced number of macrophages observed in the lesion site in the aorta of SPI+- or SPI(-)-fed mice compared with CAS-fed mice. In an in vitro LPS-induced inflamm...Continue Reading

References

Mar 15, 1993·Annals of the New York Academy of Sciences·C R SirtoriM R Lovati
Jan 1, 1997·The American Journal of Clinical Nutrition·C R SirtoriP A Murphy
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M S AnthonyJ D Wagner
Mar 17, 1999·The Journal of Clinical Investigation·J GoslingI F Charo
Sep 23, 2000·Nature·A J Lusis
Oct 4, 2000·The Journal of Nutrition·M R LovatiC R Sirtori
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael R AdamsJ Koudy Williams
Dec 20, 2002·Nature·Peter Libby
Feb 28, 2004·The Journal of Nutrition·Michael R AdamsMary S Anthony
Apr 5, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Balu K ChackoRakesh P Patel
Apr 15, 2006·The Journal of Nutrition·Liwei GuThomas M Badger
Jan 24, 2007·The Journal of Nutrition·Balu K ChackoRakesh P Patel

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Citations

Nov 18, 2008·Canadian Journal of Physiology and Pharmacology·Juejin WangShengnan Li
Mar 25, 2011·Critical Reviews in Food Science and Nutrition·R GonzálezF Sánchez de Medina
Jun 15, 2011·Bioscience, Biotechnology, and Biochemistry·Katsumi Imaizumi
Oct 27, 2015·Molecular Nutrition & Food Research·Narges YazdekhastiGabriele I Stangl
Sep 8, 2016·International Journal of Molecular Medicine·Haian LimChul-Ho Lee
Mar 23, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Barbara BonacasaGiovanni E Mann
Aug 24, 2013·PloS One·Alison R LeeAnne A Knowlton
Nov 2, 2018·Journal of Nutritional Science and Vitaminology·Hsing-Chun LinJeng-Yuan Chiou
Sep 5, 2009·The British Journal of Nutrition·Toshiro MatsuiKiyoshi Matsumoto
Jan 10, 2010·Food & Function·Min-Hsiung PanChi-Tang Ho
Feb 15, 2014·BioMed Research International·Subhadeep ChakrabartiJianping Wu
Sep 18, 2015·Frontiers in Plant Science·Ibrahim JantanSyed Nasir Abbas Bukhari

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