PMID: 9187629Jun 1, 1997Paper

Dietary stearic acid reduces plasma and hepatic cholesterol concentrations without increasing bile acid excretion in cholesterol-fed hamsters

The Journal of Nutrition
C A HasselD D Gallaher

Abstract

Although there is general agreement that saturated fatty acids elevate plasma cholesterol concentrations, the relative effects of individual fatty acids on cholesterol and bile acid metabolism are less clear. In this study, cholesterol and bile acid responses to diets enriched in different saturated fatty acids were investigated in hamsters. The six diets examined were as follows: 5% fat (g/100 g) enriched in palmitic acid (16:0) with no cholesterol, 5% fat 16:0-enriched, 0.05% cholesterol (wt/wt), and four diets containing 0.05% cholesterol and 15% fat with each diet enriched in lauric (12:0), myristic (14:0), palmitic (16:0), or stearic acid (18:0). Total plasma cholesterol concentration was significantly greater in hamsters fed the 14:0-enriched diet relative to those fed the 18:0-enriched diet (P < 0.05). Both plasma and liver cholesterol concentrations of hamsters fed 18:0 did not differ from those of the group fed no dietary cholesterol. In all instances, differences in total plasma cholesterol were accounted for within the HDL fraction; no significant treatment differences in VLDL or LDL cholesterol were found. Total daily fecal bile acid excretion was higher in hamsters fed the 15% fat 16:0 diet compared with those fed ...Continue Reading

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Citations

Jan 13, 2006·Critical Reviews in Food Science and Nutrition·J Bruce German, Cora J Dillard
Apr 28, 2006·International Journal of Food Sciences and Nutrition·A Saari CsallanyK L Fritz
Oct 24, 2006·The Journal of Nutrition·Heather E RasmussenTimothy P Carr
Apr 3, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L B OliverosM S Giménez
Oct 9, 2002·The Journal of Nutrition·Russell L CowlesTimothy P Carr
Aug 6, 2019·Advanced Pharmaceutical Bulletin·Revathy SreedharSabitha Mangalathillam
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·T P CarrC L Schneider

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