Dietary sugar inhibits satiation by decreasing the central processing of sweet taste.

ELife
Christina E MayMonica Dus

Abstract

From humans to vinegar flies, exposure to diets rich in sugar and fat lowers taste sensation, changes food choices, and promotes feeding. However, how these peripheral alterations influence eating is unknown. Here we used the genetically tractable organism D. melanogaster to define the neural mechanisms through which this occurs. We characterized a population of protocerebral anterior medial dopaminergic neurons (PAM DANs) that innervates the β'2 compartment of the mushroom body and responds to sweet taste. In animals fed a high sugar diet, the response of PAM-β'2 to sweet stimuli was reduced and delayed, and sensitive to the strength of the signal transmission out of the sensory neurons. We found that PAM-β'2 DANs activity controls feeding rate and satiation: closed-loop optogenetic activation of β'2 DANs restored normal eating in animals fed high sucrose. These data argue that diet-dependent alterations in taste weaken satiation by impairing the central processing of sensory signals.

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Citations

Nov 13, 2020·Science Advances·Anoumid VaziriMonica Dus
Apr 13, 2021·Frontiers in Behavioral Neuroscience·Deepthi MahishiWolf Huetteroth
Jun 17, 2021·Neurochemistry International·Anoumid Vaziri, Monica Dus
Oct 21, 2021·Journal of Neurophysiology·Aaron P Cook, Michael P Nusbaum

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Methods Mentioned

BETA
transgenic
Protein assay

Software Mentioned

R
OptoFLIC
FlyLight

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