Dietary supplement of omega-3 fatty acids has no effect on acute collagen-induced thrombus formation in flowing native blood

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
R M BarstadK S Sakariassen

Abstract

We have studied the effect of a daily supplement of 2.4 omega-3 fatty acids (omega 3 FAs) to 16 healthy men on acute collagen-induced thrombus formation in flowing non-anticoagulated blood. The supplement was formulated as Triomar capsules, containing 60% omega-3 FAs with an eicosapentaenoic/docosahexaenoic acid ratio of 3/2. A parallel-plate perfusion chamber device was used to study thrombus formation prior to and after 3 months of omega-3 FAs supplement. The wall shear rates at the thrombogenic surface were 650, 2,600 and 10,500 s-1, which are typical for small arteries, slightly stenosed arteries and severely stenosed arteries, respectively. For the latter situation a parallel-plate perfusion chamber with an eccentric stenosis occluding 80% of the cross-sectional area of the blood flow channel was used. The dietary supplement of omega-3 FAs did not cause significant changes in platelet adhesion to collagen or in thrombus volume. However, fibrin deposition was reduced by 34% (P < 0.03) at the highest shear condition (stenosis). Plasma fibrinogen was reduced by 18% (P < 0.0006). Changes in serum concentration of triglycerides, total-cholesterol, LDL- and HDL-cholesterol were not significant. Our data suggest that a moderate i...Continue Reading

Citations

Oct 1, 2013·Biomedical Microdevices·Lauren D C Casa, David N Ku
Nov 10, 2001·Annual Review of Biomedical Engineering·D M Wootton, D N Ku
Oct 1, 2004·Journal of Thrombosis and Haemostasis : JTH·K S SakariassenH R Baumgartner
May 20, 1998·American Heart Journal·S R Hanson, K S Sakariassen
Nov 17, 2004·Thrombosis Journal·Robert H Williams, Matthias U Nollert

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