Dietary Supplementation with a Combination of Lactoferrin, Fish Oil, and Enterococcus faecium WB2000 for Treating Dry Eye: A Rat Model and Human Clinical Study

The Ocular Surface
Motoko KawashimaKazuo Tsubota

Abstract

To examine the effect of a combined dietary supplement containing fish oil, lactoferrin, zinc, vitamin C, lutein, vitamin E, γ-aminobutanoic acid, and Enterococcus faecium WB2000 on dry eye. A preliminary study in a rat model and a prospective, randomized, double-blind, placebo-controlled study in humans were conducted. Forty Japanese volunteers aged 22 to 59 years were randomized into combined dietary supplement (2 capsules/day; 20 participants) and placebo (vehicle; 19 participants) groups and treated once daily for 8 weeks. Rats received the combined dietary supplement components (10 or 50 mg/kg orally) or vehicle (2% DMSO), and dry eye was mechanically induced for 2 days. Tear production was measured in rats after dry eye was induced. Humans were assessed at baseline and weeks 4 and 8 post-supplementation based on keratoconjunctival epithelial damage; fluorescein tear film breakup time; tear production; biochemical data; information regarding subjective dry eye symptoms by answering a questionnaire; and information regarding adverse events via medical interviews. Supplementation dose-dependently mitigated the decrease in tear production in rats. Among subjects with confirmed dry eye, clinical symptoms improved at weeks 4 an...Continue Reading

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Aug 21, 2013·JAMA Ophthalmology·Yuri SakaneYuichi Ohashi

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Citations

Oct 1, 2016·Pharmaceuticals·Francesco GiansantiGiovanni Antonini
Aug 24, 2017·Acta Ophthalmologica·Sophia Seen, Louis Tong
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Shigeru Nakamura
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Motoko Kawashima
Jul 3, 2019·Antibiotics·Azadeh Tavakoli, Judith Louise Flanagan
Dec 18, 2019·The Cochrane Database of Systematic Reviews·Laura E DownieEsen K Akpek
Oct 3, 2018·Ocular Immunology and Inflammation·Shasha WangJianhong Zhang
Jan 28, 2021·Scientific Reports·Hayato NagashimaKazuo Tsubota
Nov 14, 2020·International Journal of Molecular Sciences·Jayoon MoonMee Kum Kim
Jan 12, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Sara MohamedAhmed G Abdelhamid

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