Dietary supplementation with fructooligosaccharides attenuates allergic peritonitis in mice

Biochemical and Biophysical Research Communications
Akiko YasudaHirohisa Takano

Abstract

Fructooligosaccharides (FOS) are a prebiotic supplement, which can enhance immunological responses in the host to activate mucosal immunity probably through regulation of gastrointestinal microflora. Nonetheless, the therapeutic potential of prebiotics on allergic pathologies has not been fully elucidated. Therefore, the purpose of this study was to evaluate the preventive and therapeutic effects of dietary supplementation with FOS on a murine model of allergic peritonitis induced by ovalbumin (OVA). Male C3H/HeN mice were intraperitoneally administrated with OVA (1 μg) bi-weekly (Day 0-42, total four times) and were fed a diet containing 0 or 2.5% FOS ad libitum (Day 7-43). At Day 43, mice were killed and several parameters were evaluated. As results, supplementation with FOS alleviated OVA-related peritoneal inflammation characterized by trafficking of polymorphonuclear leukocytes such as eosinophils and neutrophils in the peritoneal cavity. Also, FOS significantly suppressed the protein level of interleukin (IL)-5 and eotaxin in the peritoneal lavage fluid elicited by OVA. In addition, a FOS-supplemented diet significantly reduced the serum allergen specific-IgG(1) level, whereas it significantly increased total IgA levels i...Continue Reading

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Citations

Jul 24, 2013·BMC Veterinary Research·Johannes Cornelis VendrigJohanna Fink-Gremmels
Jan 28, 2014·PloS One·Mercedes Ortega-GonzálezDaddaoua Abdelali
Aug 28, 2014·Critical Reviews in Food Science and Nutrition·Hanru WangGordon S Howarth
Nov 20, 2014·BMC Veterinary Research·Johannes Cornelis VendrigJohanna Fink-Gremmels
Nov 21, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J KerperienL M J Knippels
Apr 1, 2014·Current Opinion in Biotechnology·Cory KlemashevichArul Jayaraman
Jul 23, 2014·Journal of Food Science·Damini KothariArun Goyal
Feb 24, 2016·World Journal of Gastroenterology : WJG·Eleonora DistruttiStefano Fiorucci
Mar 11, 2020·Frontiers in Microbiology·José Manuel Rubio-GómezAbdelali Daddaoua
May 21, 2019·Critical Reviews in Microbiology·Shanshan ZhongChuansheng Zhao

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