PMID: 9446842Mar 7, 1998Paper

Dietary supplementation with mushroom-derived protein-bound glucan does not enhance immune function in young and old mice

The Journal of Nutrition
D WuS N Meydani

Abstract

Decline in immune response is a well-documented age-associated biological change. Protein-bound polysaccharides (PSP) are biological response modifiers and have been shown to have immunoenhancing and antitumor effects. This study was conducted to examine the effect of dietary supplementation with PSP-containing extract derived from mycelia of Coriolus versicolor on in vitro and in vivo indices of immune function of young and old mice. Young (5 mo) and old (23 mo) C57BL/6NIA mice were fed purified diets containing 0, 0.1, 0.5 or 1.0% PSP for 1 mo at which time indices of immune function were measured. PSP supplementation had no significant effect on mitogenic response to concanavalin A (Con A), phytohemagglutinin (PHA) or lipopolysaccharide (LPS), or on production of interleukin (IL)-1, IL-2, IL- 4 and prostaglandin E2 (PGE2). Of the in vivo indices of immune function tested, old mice fed 1.0% PSP had significantly higher delayed-type hypersensitivity (DTH) response than those fed 0% PSP. No significant effect of PSP was observed on the DTH response of young mice. The antibody response to sheep red blood cells was not significantly influenced by PSP in young or old mice. These results suggest that PSP-containing extract from myc...Continue Reading

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Citations

Dec 29, 2005·Journal of Medicinal Food·Eun-Mi ChoiJae-Kwan Hwang
Sep 7, 2012·Rejuvenation Research·Jiangshui YuanShicui Zhang
Sep 17, 2013·Molecular Nutrition & Food Research·Uma S BabuMona S Calvo
Jun 25, 2005·The Journal of Pharmacology and Experimental Therapeutics·Peter J RiceDavid L Williams
Nov 9, 2010·Journal of Agricultural and Food Chemistry·Jian-Nan ChenJames Swi-Bea Wu
Jul 20, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Paul ThomesRamasamy Rengasamy

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