PMID: 2106017Jan 1, 1990Paper

Dietary supplementation with oils rich in (n-3) and (n-6) fatty acids influences in vivo levels of epidermal lipoxygenase products in guinea pigs

The Journal of Nutrition
C C MillerM P Fletcher

Abstract

Certain dietary oils may have therapeutic potential in the treatment of inflammatory skin disorders. Presumably, the fatty acid constituents of these dietary oils exert their effects by altering the levels of cutaneous eicosanoids. Prompted by this possibility, we investigated whether supplementation of guinea pig diets with fish oil [rich in 20:5(n-3)] or borage oil [rich in 18:3(n-6)] could significantly alter epidermal levels of eicosanoids compared with control animals supplemented with olive oil. After feeding periods of 4, 8 or 12 wk, the epidermis from the animals was analyzed for: 1) fatty acid composition of individual epidermal phospholipids, 2) levels of lipoxygenase products, and 3) levels of cyclooxygenase products (prostaglandins). Our results demonstrated that the animals supplemented with dietary fish oil had elevated levels of 20:5(n-3) in epidermal phospholipids and elevated epidermal levels of 15-hydroxyeicosapentaenoic acid (15-HEPE) [the 15-lipoxygenase product of 20:5(n-3)] compared with guinea pigs fed olive oil or borage oil. Similarly, the animals supplemented with dietary borage oil had elevated levels of 20:3(n-6) [the epidermal elongase product of 18:3(n-6)] in epidermal phospholipids and elevated ep...Continue Reading

Citations

May 1, 2020·Nutrients·Agnieszka StawarskaBarbara Bobrowska-Korczak
Jan 1, 1993·Nutrition and Cancer·M A BeluryS M Fischer
Nov 30, 2006·Current Opinion in Gastroenterology·Robert S ChapkinJoanne R Lupton
Feb 14, 2009·Plant & Cell Physiology·Frithjof C KüpperPhilippe Potin
Jan 1, 1996·Archives of Insect Biochemistry and Physiology·R D MaddenA S Bowman
Mar 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·M ToyomizuY Tomita
Sep 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M A BeluryS M Fischer
Jul 14, 2010·Clinics in Dermatology·Meagen M McCusker, Jane M Grant-Kels
Jun 29, 2010·Nutrition·Rachel H FosterRaid G Alany

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