Dietary supplementation with probiotics improves hematopoiesis in malnourished mice.

PloS One
Susana SalvaSusana Alvarez

Abstract

Lactobacillus rhamnosus CRL1505 (Lr) administered during the repletion of immunocompromised-malnourished mice improves the resistance against intestinal and respiratory infections. This effect is associated with an increase in the number and functionality of immune cells, indicating that Lr could have some influence on myeloid and lymphoid cell production and maturation. This study analyzed the extent of the damage caused by malnutrition on myeloid and lymphoid cell development in the spleen and bone marrow (BM). We also evaluated the impact of immunobiotics on the recovery of hematopoiesis affected in malnourished mice. Protein malnourished mice were fed on a balanced conventional diet for 7 or 14 consecutive d with or without supplemental Lr or fermented goat's milk (FGM). Malnourished mice and well-nourished mice were used as controls. Histological and flow cytometry studies were carried out in BM and spleen to study myeloid and lymphoid cells. Malnutrition induced quantitative alterations in spleen B and T cells; however, no alteration was observed in the ability of splenic B cells to produce immunoglobulins after challenge with LPS or CpG. The analysis of BM B cell subsets based on B220, CD24, IgM and IgD expression showed...Continue Reading

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Feb 3, 2016·Journal of Zhejiang University. Science. B·Zhuo-ping YuWei Chen
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May 24, 2017·Frontiers in Immunology·Susana Salva, Susana Alvarez

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Methods Mentioned

BETA
ELISA
flow cytometry
FACS

Software Mentioned

TreeStar
FlowJo

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