Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte DHA and EPA to fish oil in healthy humans.

The British Journal of Nutrition
Annette L WestG C Burdge

Abstract

EPA and DHA are required for normal cell function and can also induce health benefits. Oily fish are the main source of EPA and DHA for human consumption. However, food choices and concerns about the sustainability of marine fish stocks limit the effectiveness of dietary recommendations for EPA + DHA intakes. Seed oils from transgenic plants that contain EPA + DHA are a potential alternative source of EPA and DHA. The present study investigated whether dietary supplementation with transgenic Camelina sativa seed oil (CSO) that contained EPA and DHA was as effective as fish oil (FO) in increasing EPA and DHA concentrations when consumed as a dietary supplement in a blinded crossover study. Healthy men and women (n 31; age 53 (range 20-74) years) were randomised to consume 450 mg/d EPA + DHA provided either as either CSO or FO for 8 weeks, followed by 6 weeks washout and then switched to consuming the other test oil. Fasting venous blood samples were collected at the start and end of each supplementation period. Consuming the test oils significantly (P < 0·05) increased EPA and DHA concentrations in plasma TAG, phosphatidylcholine and cholesteryl esters. There were no significant differences between test oils in the increments of...Continue Reading

References

Sep 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T A SandersG R Thompson
Feb 27, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·B A Griffin, B A Fielding
Jun 23, 2004·Preventive Medicine·William S Harris, Clemens Von Schacky
Aug 24, 2004·The American Journal of Clinical Nutrition·Sabine TriconPhilip C Calder
Dec 22, 2004·Annals of Internal Medicine·Jennifer Fisher Wilson
May 24, 2008·The Proceedings of the Nutrition Society·D Ian Givens, Rachael A Gibbs
Jun 12, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A H MetherelK D Stark
Dec 7, 2013·The Plant Journal : for Cell and Molecular Biology·Noemi Ruiz-LopezOlga Sayanova
Apr 2, 2014·Journal of Visualized Experiments : JoVE·Helena L FiskPhilip C Calder
Jan 31, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Norman Salem, Manfred Eggersdorfer
Jul 17, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Philip C Calder
Jan 8, 2016·Nutrients·Lotte LauritzenCarlo Agostoni
Nov 5, 2016·Progress in Lipid Research·Ella J BakerPhilip C Calder
Dec 7, 2017·Journal of Nutritional Science·Graham C BurdgeChristiani Jeyakumar Henry
Apr 15, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Annette L WestGraham C Burdge

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
NMR

Clinical Trials Mentioned

NCT03477045

Software Mentioned

SPSS Statistics
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.