Dietary tributyrin, an HDAC inhibitor, promotes muscle growth through enhanced terminal differentiation of satellite cells

Physiological Reports
Robert L MurrayChad H Stahl

Abstract

Muscle growth and repair rely on two main mechanisms - myonuclear accretion and subsequent protein accumulation. Altering the ability of muscle resident stem cells (satellite cells) to progress through their myogenic lineage can have a profound effect on lifetime muscle growth and repair. The use of the histone deacetylase (HDAC) inhibitor, butyrate, has had positive outcomes on the in vitro promotion of satellite cell myogenesis. In animal models, the use of butyrate has had promising results in treating myopathic conditions as well as improving growth efficiency, but the impact of dietary butyrate on satellite cells and muscle growth has not been elucidated. We investigated the impact of tributyrin, a butyrate prodrug, on satellite cell activity and muscle growth in a piglet model. Satellite cells from tributyrin-treated piglets had altered myogenic potential, and piglets receiving tributyrin had a ~40% increase in DNA:protein ratio after 21 days, indicating the potential for enhanced muscle growth. To assess muscle growth potential, piglets were supplemented tributyrin (0.5%) during either the neonatal phase (d1-d21) and/or the nursery phase (d21-d58) in a 2 × 2 factorial design. Piglets who received tributyrin during the ne...Continue Reading

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Dec 12, 2018·Expert Opinion on Investigational Drugs·Fabio Penna, Paola Costelli
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Apr 11, 2020·Journal of Agricultural and Food Chemistry·Cheng-Long JinXiu-Qi Wang

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Datasets Mentioned

BETA
100625823

Methods Mentioned

BETA
acetylation

Software Mentioned

Zeiss ZEN Pro
ZenPro
GraphPad
Image Lab
CFX Manager
Zeiss AxioObserver
GraphPad Prism
SAS
Gen

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