PMID: 6170074Sep 1, 1981Paper

Dietary tryptophan reversal of septal lesion and 5,7-DHT lesion elicited shock-induced fighting

Pharmacology, Biochemistry, and Behavior
K M KantakB Eichelman

Abstract

Using two procedures known to enhance shock-induced defensive fighting (SIF) and mouse-killing--septal lesions and 5,7-DHT lesions--we determined if a 5% tryptophan-loaded diet could reverse the lesion effects. The results indicated that SIF, but not mouse-killing, could be maintained at normal levels following dietary tryptophan loading in both septally lesioned and 5,7-DHT lesioned rats. This behavioral reversal was independent of pain sensitivity, feeding, drinking and body weight levels. Regional brain analysis of monoamines and metabolites indicated that the lesions produced substantial depletions in 5-HT and 5-HIAA with minimal reduction or no change in catecholamines. Dietary tryptophan loading elevated 5-HT and 5-HIAA in unlesioned animals and partially restored 5-HT and 5-HIAA levels in lesioned animals. These patterns of depletion and repletion were confined to the hippocampus following septal lesions and distributed throughout the brain following 5,7-DHT lesions. The results are discussed in terms of a possible hippocampal mediation of the dietary tryptophan reversal in shock-induced defensive fighting following lesioning.

References

Mar 1, 1976·Neuropharmacology·C A Marsden, G Curzon
Apr 1, 1976·Pharmacology, Biochemistry, and Behavior·A B JonesB Eichelman
Feb 12, 1979·Life Sciences·E C Hwang, M H Van Woert
Mar 1, 1979·Pharmacology, Biochemistry, and Behavior·R F Smith
Mar 1, 1975·Pharmacology, Biochemistry, and Behavior·K Hole, C A Marsden
Apr 1, 1972·Journal of Comparative and Physiological Psychology·K A Miczek, S P Grossman
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Feb 1, 1980·Pharmacology, Biochemistry, and Behavior·K M KantakB Eichelman
Aug 29, 1980·European Journal of Pharmacology·P SeemanJ J Warsh

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Citations

Dec 1, 1987·Pharmacology, Biochemistry, and Behavior·B ChamberlainS N Young
Oct 1, 1988·Pharmacology, Biochemistry, and Behavior·D C BlanchardK Hori
Mar 1, 1984·Brain Research Bulletin·K M KantakB Eichelman
Dec 1, 1989·Journal of Neurochemistry·J D Schaechter, R J Wurtman

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