Dietary vitamin A intake and the risk of ovarian cancer: a meta-analysis.

Bioscience Reports
Qiaoqiao Wang, Chaying He

Abstract

Previous studies have demonstrated some associations between dietary vitamin A intake and ovarian cancer risk with an inconsistent relationship. We therefore performed the present study to further explore the association between them. Databases of PubMed, Embase, and Web of Science were retrieved up to September 1, 2019. Summarized relative risk (RR) with corresponding 95% confidence intervals (CI) were calculated. Stata 14.0 software was used for data analysis. Fifteen articles involving 4882 cases and 443,179 participants were included in this meta-analysis. A positive association between dietary vitamin A intake and ovarian cancer risk was found (RR = 0.816, 95%CI = 0.723-0.920, I2 = 48.4%, Pfor heterogeneity = 0.019). Significant association was also found in case-control studies (RR = 0.769, 95%CI = 0.655-0.902), but not in cohort studies. When we performed the analysis between ovarian cancer risk and geographic locations, we found an inverse association in North American populations (RR = 0.825, 95%CI = 0.720-0.946), instead of other populations. In summary, findings from the present study suggested that higher dietary intake of vitamin A may contribute to the lower development of ovarian cancer, especially among North Am...Continue Reading

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Citations

May 3, 2020·Cellular and Molecular Life Sciences : CMLS·Anuradha KirtoniaManoj Garg
Feb 3, 2021·Antioxidants·Tsukuru AmanoTokuhiro Chano
Mar 23, 2021·Frontiers in Pharmacology·Umme Tamanna Ferdous, Zetty Norhana Balia Yusof
Aug 31, 2021·Frontiers in Oncology·Jian-Zeng GuoTing-Ting Gong

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