Dietary vitamin A supplementation prevents early obesogenic diet-induced microbiota, neuronal and cognitive alterations.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Essi F BiyongG. Ferreira

Abstract

Early consumption of obesogenic diets, rich in saturated fat and added sugar, is associated with a plethora of biological dysfunctions, at both peripheral and brain levels. Obesity is also linked to decreased vitamin A bioavailability, an essential molecule for brain plasticity and memory function. Here we investigated in mice whether dietary vitamin A supplementation (VAS) could prevent some of the metabolic, microbiota, neuronal and cognitive alterations induced by obesogenic, high-fat and high-sugar diet (HFSD) exposure from weaning to adulthood, i.e. covering periadolescent period. As expected, VAS was effective in enhancing peripheral vitamin A levels as well as hippocampal retinoic acid levels, the active metabolite of vitamin A, regardless of the diet. VAS attenuated HFSD-induced excessive weight gain, without affecting metabolic changes, and prevented alterations of gut microbiota α-diversity. In HFSD-fed mice, VAS prevented recognition memory deficits but had no effect on aversive memory enhancement. Interestingly, VAS alleviated both HFSD-induced higher neuronal activation and lower glucocorticoid receptor phosphorylation in the hippocampus after training. Dietary VAS was protective against the deleterious effects of ...Continue Reading

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Citations

Aug 18, 2021·Neurobiology of Stress·Agnieszka KrzyżosiakWojciech Krężel

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Methods Mentioned

BETA
nuclear magnetic resonance
PCR
Illumina sequencing
16S sequencing

Software Mentioned

USEARCH
GraphPad
Hutlab
JMP
MultiQuant
Galaxy
PyNAST
SILVASSURef
Prism
FLASH

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