Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Y SunQuanjun Lu

Abstract

The meta-analysis suggested that dietary vitamin C was statistically inversely associated with the risk of hip fracture (overall OR = 0.73, 95% CI = 0.55-0.97, I 2 = 69.1%) and with the increase of 50 mg/day vitamin C intake, the risk of hip fracture will reduce by 5% (OR = 0.95, 95% CI 0.91-1.00, P = 0.05). Previous studies had inconsistent findings regarding the association between vitamin C intake and the risk of hip fracture. Therefore, we conducted a meta-analysis to evaluate the association of dietary vitamin C intake and the risk of hip fracture. Relevant studies were identified by searching PubMed, Embase, and Web of Science up to December 2016. Additional articles were identified from reviewing the reference lists of relevant articles. The summary relative risks (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by random effects model. Funnel plot and Egger's test were used to test publication bias. The total six articles containing 7908 controls and 2899 cases of hip fracture were included in this meta-analysis. By comparing the highest versus the lowest categories of vitamin C intake, we found that dietary vitamin C was statistically correlated with the risk of hip fracture [overall OR = 0....Continue Reading

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Citations

Jul 25, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W XiangX Jiang
Aug 14, 2020·Nutrients·Olga BrzezińskaKonrad Walczak
Jul 9, 2020·Nutrients·Araceli Muñoz-GarachManuel Muñoz-Torres
Dec 11, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bennett OakesFrank A Petrigliano
Aug 28, 2021·American Journal of Human Genetics·Ronit MaromBrendan Lee
Oct 14, 2021·Critical Reviews in Food Science and Nutrition·Weili FengAnqi Lu

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