Dietary whole cottonseed depresses lipogenesis but has no effect on stearoyl coenzyme desaturase activity in bovine subcutaneous adipose tissue

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
A M PageS B Smith

Abstract

The primary objective of this study was to determine the effect of long-term feeding of whole cottonseed (WCS) on lipogenesis and stearoyl-coenzyme A desaturase activity in growing steers. Brangus steers were fed either a control, cornbased diet (n = 11) or 30% WCS (n = 12). The 30% WCS contributed an estimated 6.6% additional lipid to the diet. Steers fed the added WCS had greater live weights (P = 0.04) and kidney, pelvic, and heart fat (P = 0.005). Subcutaneous fat thickness was not different (P = 0.20) between treatment groups, although WCS elicited an increase in the proportion of large diameter subcutaneous adipocytes. The rate of [U-14C]acetate incorporation into fatty acids in subcutaneous adipose tissue was reduced by dietary WCS (171.4 vs 122.1 nmol x 100 mg adipose tissue-1 x 2 hr-1, P = 0.03), indicating that the increased dietary fat depressed de novo lipogenesis. Hepatic desaturase activity was much lower than that of subcutaneous adipose tissue, a feature common to cattle. We anticipated that added WCS also would depress stearoyl-coenzyme A desaturase activity in subcutaneous adipose tissue and liver due to its cyclopropene fatty acid content. Instead, desaturase activity was numerically (although not significant...Continue Reading

References

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Citations

Oct 4, 2012·Animal : an International Journal of Animal Bioscience·K J ShingfieldN D Scollan
Sep 27, 2005·Critical Reviews in Food Science and Nutrition·Tilak R DhimanAmy L Ure
May 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Xiaoming BaoJohn Ohlrogge
Sep 19, 2009·Nutrition & Metabolism·Sailas Benjamin, Friedrich Spener
Feb 4, 2003·The Journal of Biological Chemistry·Xiaoming BaoJohn B Ohlrogge
Mar 23, 2004·Journal of Animal Science·M J Azain
Aug 26, 2021·EFSA Journal·UNKNOWN EFSA Panel on Genetically Modified Organisms (GMO)Tommaso Raffaello

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