PMID: 8613886Apr 1, 1996Paper

Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver

The Journal of Nutrition
A S Om, K W Chung

Abstract

We studied the effects of zinc deficiency on hepatic androgen metabolism and aromatization, androgen and estrogen receptor binding, and circulating levels of reproductive hormones in freely fed, pair-fed and zinc deficient rats. Hepatic conversion of testosterone to dihydrotestosterone was significantly less, but formation of estradiol from testosterone was significantly greater in rats fed the zinc-deficient diet compared with freely fed and pair-fed control rats. There were significantly lower serum concentrations of luteinizing hormone, estradiol and testosterone in rats fed the zinc-deficient diet. No difference in the concentration of serum follicle-stimulating hormone was observed between the zinc-deficient group and either control group. Scatchard analyses of the receptor binding data showed a significantly higher level of estrogen receptor in zinc-deficient rats (36.6 +/- 3.4 fmol/mg protein) than in pair-fed controls (23.3 +/- 2.2 fmol/mg protein) and a significantly lower level of androgen binding sites in rats fed the zinc-deficient diet (6.7 +/- 0.7 fmol/mg protein) than in pair-fed control rats (11.3 +/- 1.2 fmol/mg protein). There were no differences in hepatic androgen and estrogen receptor levels between freely ...Continue Reading

Citations

Aug 2, 2012·Nutrients·Bruce J Grattan, Hedley C Freake
Sep 13, 2013·Current Urology Reports·Philippa J Cheetham
May 15, 2008·Andrologia·A M El-Tawil
Mar 4, 2020·Biological Trace Element Research·Ulvi AliyevOrhan Derman
Jul 29, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Malcolm CarruthersMark R Feneley
Mar 15, 2016·Frontiers in Behavioral Neuroscience·Stefanie GrabruckerAndreas M Grabrucker
Feb 24, 2012·The Journal of Nutrition·Colleen DempseyShannon L Kelleher
Mar 31, 2016·Biological Trace Element Research·Krishna Prahlad MaremandaG B Jena
Aug 3, 2018·Journal of the International Society of Sports Nutrition·Chad M KerksickRichard B Kreider
Dec 4, 2012·Current Opinion in Urology·Geovanni Espinosa
Apr 29, 2016·International Journal of Molecular Medicine·Qingqing ChuPing Zhang
Jun 8, 2012·Histochemistry and Cell Biology·Man-Li ZhongZhan-You Wang
May 10, 2000·The Journal of Nutrition·N F Shay, H F Mangian
Aug 3, 2021·BioMed Research International·Mabrouka LtaifAhlem Soussi

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