Dietary Zinc Modulates Matrix Metalloproteinases in Traumatic Brain Injury

Journal of Neurotrauma
Angus G ScrimgeourMarloes J A Joosen

Abstract

Animal models of mild traumatic brain injury (mTBI) provide opportunity to examine the extent to which dietary interventions can be used to improve recovery after injury. Animal studies also suggest that matrix metalloproteinases (MMPs) play a role in tissue remodeling post-TBI. Because dietary zinc (Zn) improved recovery in nonblast mTBI models, and the MMPs are Zn-requiring enzymes, we evaluated the effects of low- (LoZn) and adequate-Zn (AdZn) diets on MMP expression and behavioral responses, subsequent to exposure to a single blast. MMP messenger RNA expression in soleus muscle and frontal cortex tissues were quantified at 48 h and 14 days post-blast. In muscle, blast resulted in significant upregulation of membrane-type (MT)-MMP, MMP-2, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 at 48 h post-injury in rats consuming AdZn. At 14 days post-blast, there were no blast or dietary effects observed on MMP levels in muscle, supporting the existence of a Zn-responsive, functional repair and remodeling mechanism. In contrast, blast resulted in a significant downregulation of MT-MMP, TIMP-1, and TIMP-2 and a significant upregulation of MMP-3 levels at 48 h post-injury in cortex tissue, whereas at 14 days post-blast, MT...Continue Reading

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Citations

Oct 19, 2019·Biological Trace Element Research·Jing-Wen CaoMengyao Guo
Mar 12, 2019·Current Opinion in Critical Care·Hervé Quintard, Carole Ichai
Aug 23, 2020·Medical Sciences : Open Access Journal·Cathy W Levenson
Dec 2, 2020·International Journal of Molecular Sciences·Seunghyuk ChoiSang Won Suh
Jan 9, 2021·Fluids and Barriers of the CNS·Gozde UzunalliL Tiffany Lyle
Mar 18, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Patrycja KupnickaIrena Baranowska-Bosiacka
Apr 27, 2021·Pharmacology & Therapeutics·Xiao-Yuan MaoWei-Lin Jin

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Datasets Mentioned

BETA
GM6001

Methods Mentioned

BETA
sedation
PCR

Software Mentioned

BLAST
Primer Design

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