Dietary zinc supplementation increased TNFα and IL1β-induced RANKL expression, resulting in a decrease in bone mineral density in rats

Journal of Clinical Biochemistry and Nutrition
Takako SuzukiKazuharu Suzuki

Abstract

We investigated the effect of dietary zinc supplementation on bone metabolism in rats. Four-week-old male Wistar rats were fed a 30.0 mg zinc/kg diet (C), a 300.0 mg zinc/kg diet (HZ) or a 3,000.0 mg zinc/kg diet (EZ) for 4 weeks. The zinc content of the femur gradually increased in accordance with the gradual increase in the dietary zinc level. Although the mRNA expression of zinc transporters in bone did not differ between the groups, the mRNA expression of metallothioneins was increased in the HZ and EZ groups compared to the C group. Moreover, the bone mineral density was significantly decreased in the HZ and EZ groups compared to the C group. Furthermore, the mRNA expression of tumor necrosis factor α, Interleukin-1β and osteoclastogenesis-related genes such as receptor for activator of nuclear factor-κB (NF-κB) ligand, tumor necrosis factor receptor-associated factor 6, and nuclear factor of activated T cells cytoplasmic 1 was significantly increased in the HZ and EZ groups compared to the C group. These findings suggested that dietary zinc supplementation reduced bone mineral density through the promotion of bone resorption via an increase in the expression of receptor for activator of NF-κB ligand induced by tumor necro...Continue Reading

References

May 1, 1977·The Journal of Nutrition·R W ChenP D Whanger
Jan 1, 1989·The American Journal of Clinical Nutrition·M K YadrickE A Winterfeldt
Jan 1, 1987·Experientia. Supplementum·R D AndersenH R Herschman
Jul 1, 1983·Journal of Animal Science·G M Hill, E R Miller
Mar 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B S Moonga, D W Dempster
Sep 1, 1993·General Pharmacology·A TogariS Matsumoto
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·R J McMahon, R J Cousins
May 23, 2001·Experimental Biology and Medicine·S F Simon, C G Taylor
Jun 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N L FazzalariD M Findlay
Jul 4, 2002·Human Molecular Genetics·Koichi InoueToshihiro Tanaka
Jul 5, 2002·The Journal of Nutrition·Carmen M DonangeloJanet C King
Sep 27, 2002·The American Journal of Clinical Nutrition·Susilowati HermanSteven A Abrams
Oct 9, 2002·Journal of Pediatric Hematology/oncology·Mark B SalzmanCharles Koo
May 16, 2003·Nature·Shun-ichi Harada, Gideon A Rodan
May 16, 2003·Pflügers Archiv : European journal of physiology·Richard D Palmiter, Liping Huang
May 16, 2003·Pflügers Archiv : European journal of physiology·David J Eide
Jul 12, 2005·Bone·Mohammed A KhadeerAnandarup Gupta
Oct 26, 2005·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Milan Vasák
Nov 14, 2006·Bone·Masataka Asagiri, Hiroshi Takayanagi
Oct 24, 2007·The Journal of Biological Chemistry·Liping HuangKent K C Lloyd
Apr 15, 2008·Experimental Biology and Medicine·Sarah M KingJanet C King
Apr 30, 2009·Annual Review of Nutrition·Louis A Lichten, Robert J Cousins
Sep 18, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yang SongEmily Ho
Aug 18, 2010·Oral and Maxillofacial Surgery Clinics of North America·Amjad JavedFarah Y Ghori
Oct 19, 2010·Biological Trace Element Research·Jian-Yi SunXiao-Yan Weng
Mar 2, 2011·Biological Trace Element Research·Ersan KaraRasim Mogulkoc
Feb 1, 2012·Biochemical and Biophysical Research Communications·Jung-Hoon OhJung-Eun Kim
Oct 4, 2013·Cell Communication and Signaling : CCS·Kwang Hwan ParkJae Myun Lee
Sep 6, 2014·Nutrients·Naira Josele Neves de BritoJosé Brandão-Neto

❮ Previous
Next ❯

Citations

Mar 5, 2016·Bioscience, Biotechnology, and Biochemistry·Takako SuzukiKazuharu Suzuki
Aug 9, 2018·Journal of Clinical Biochemistry and Nutrition·Yu MatsumotoYoshiko Ishimi

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
X-ray
electrophoresis
PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Lucia S GrahamRita B Effros
Journal of Nutritional Science and Vitaminology
Shinichi KatsumataMarlena C Kruger
© 2022 Meta ULC. All rights reserved