PMID: 3754554Apr 1, 1986Paper

Diethylcarbamazine on pulmonary vascular response to endotoxin in awake sheep

Journal of Applied Physiology
A ZadoffJ H Newman

Abstract

Diethylcarbamazine (DEC) is an inhibitor of lipoxygenase, with protective effects in several experimental models of anaphylaxis and lung dysfunction. The hypothesis of this study was that DEC would alter the pulmonary response to endotoxin infusion, especially the prolonged pulmonary hypertension, leukopenia, hypoxemia, and high flow of protein-rich lung lymph. We prepared sheep for chronic measurements of hemodynamics and collection of lung lymph. In paired studies we gave six sheep endotoxin (0.5 micrograms/kg iv) either with or without DEC. DEC was given (80-100 mg/kg iv) over 30 min followed by a continuous infusion at 1 mg X kg-1 X min-1. Endotoxin was given after the loading infusion of DEC, and variables were monitored for 4 h. The response to endotoxin was characterized by pulmonary hypertension, leukopenia, hypoxemia, and elevations of thromboxane B2 and 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha). Lymph flow and protein content reflected hemodynamic and permeability changes in the pulmonary circulation. DEC did not significantly modify the response to endotoxin by any measured variable, including pulmonary arterial and left atrial pressures, cardiac output, lymph flow and protein content, alveolar-to-arterial PO2...Continue Reading

Citations

Oct 12, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mauricio RojasKenneth L Brigham
Oct 1, 1992·The American Review of Respiratory Disease·R F MillerJ R Snapper
Jan 1, 1988·Molecular Aspects of Medicine·N C OlsonC E McCall
Jul 1, 1987·Prostaglandins, Leukotrienes, and Medicine·N C OlsonL N Fleisher

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