PMID: 7541501Jan 1, 1995Paper

Diethyldithiocarbamate ameliorates the effect of lipopolysaccharide on both increased nitrite production by vascular smooth muscle cells and decreased contractile response of aortic rings

Life Sciences
D J LoegeringG A Wirth

Abstract

The depression of vasoconstrictor responsiveness caused by bacterial lipopolysaccharide (LPS) is mediated, in part, by the induction of nitric oxide synthase (NOS) and the resultant increase in nitric oxide production by vascular smooth muscle. The present study evaluated the ability of the antioxidant, diethyldithiocarbamate (DDTC), to attenuate the LPS-stimulated induction of NOS in cultured vascular smooth muscle cells (VSMC) and the depression of in vitro vascular reactivity caused by LPS administration to rats. The LPS-stimulated increase in nitrite production by cultured VSMC was inhibited 85% by DDTC (100 microM). When VSMC were stimulated with a combination of LPS, interferon-gamma (INF) and tumor necrosis factor (TNF) nitrite production was 5-fold greater than with LPS alone. DDTC inhibited 49% of the increase caused by LPS plus INF and TNF. Aortic rings taken from animals injected with LPS showed a depression of maximum force in response to phenylephrine which was reversed by inhibition of NOS activity. Pretreatment of animals with DDTC attenuated this depression of vascular reactivity. The DDTC treatment did not reduce the increase in serum TNF levels caused by LPS. These results suggest that DDTC can attenuate the L...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·R SchreckP A Baeuerle
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
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Citations

Dec 7, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R BertinG Froldi
Jul 31, 2007·Chemico-biological Interactions·Volodymyr I LushchakKenneth B Storey
Jun 10, 1998·Toxicon : Official Journal of the International Society on Toxinology·D V TambourgiW Dias Da Silva
Aug 30, 2008·The Journal of Organic Chemistry·Eduardo HumeresNito Angelo Debacher

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