Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol

Magnetic Resonance in Chemistry : MRC
Manuela E GarcíaRoberto R Gil

Abstract

Residual dipolar couplings (RDCs) constitute an important NMR parameter for structural elucidation in all areas of chemistry. In this study, di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-based gels are introduced as alignment media for the measurement of RDCs of small organic molecules in polar solvents such as methanol. The low viscosity of methanol permits the execution of J-scaled BIRD HSQC experiments that yield very sharp lines in anisotropic conditions. The gels have excellent mechanical properties, and their compression and expansion in the swollen state can be reversed and performed multiple times. This process enables the easy loading and release of analytes. The excellent performance of these new aligning gels is demonstrated by analyzing the structure of the alkaloid retrorsine. Copyright © 2016 John Wiley & Sons, Ltd.

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Citations

Jun 14, 2016·Journal of the American Chemical Society·Nilamoni NathYizhou Liu
Dec 16, 2016·Magnetic Resonance in Chemistry : MRC·Carla Rigling, Marc-Olivier Ebert
Apr 7, 2017·Chemistry : a European Journal·Gao-Wei LiRen Xiang Tan
Jul 4, 2020·Journal of Biomolecular NMR·Reto HorstJane M Withka
Jun 27, 2018·Natural Products and Bioprospecting·Gao-Wei LiXin-Xiang Lei
Dec 16, 2018·Nature Protocols·Yizhou LiuR Thomas Williamson
Apr 16, 2021·Magnetic Resonance in Chemistry : MRC·Darcy C Burns, William F Reynolds

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