Diets containing Sophora japonica L. prevent weight gain in high-fat diet-induced obese mice

Nutrition Research
Kye Won ParkKi-Moon Park

Abstract

Obesity, a worldwide epidemic, is associated with metabolic diseases such as insulin resistance, dyslipidemia, hypertension, and heart disease. Many strategies, including natural alternative antiobesity agents, have been widely used to prevent obesity. Polyphenolic compounds and flavonoids from natural products are shown to inhibit adipogenesis. Because mature fruits of Sophora japonica L. were previously shown to contain antiadipogenic compounds, we hypothesized that diets with mature fruits of S japonica L. would prevent body weight gain in high-fat diet-induced obesity. Four-week-old mice were fed either a control high-fat diet, or high-fat diet containing 1% or 5% of S japonica L. for 4 weeks. The administration of S japonica L. fed in combination with a 30% high-fat diet significantly decreased body weight gain. S japonica L. also reduced serum and hepatic triglyceride, serum total, and high-density lipoprotein cholesterol. Consistent with the effects of lowering glucose level and fat mass, S japonica L. caused a decrease in the number of large adipocytes and a concomitant increase in the number of small adipocytes, which may explain at least in part the antiobesity effects of S japonica L. Together, these data provide evi...Continue Reading

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Citations

Feb 10, 2011·Journal of Medicinal Food·So-Ra JungKye Won Park
Dec 20, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chongming WuXi Chen
Apr 18, 2016·Journal of Ethnopharmacology·Xirui HeXiaohui Zheng
Jul 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sara ThabitMichael Wink
Jan 27, 2017·Experimental and Therapeutic Medicine·Hyoung-Min HanKyung-Hwa Kang
Jul 5, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hae-In LeeMi-Kyung Lee

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