Diets enriched with coconut, fish, or olive oil modify peripheral metabolic effects of ozone in rats.

Toxicology and Applied Pharmacology
Samantha J SnowUrmila P Kodavanti

Abstract

Dietary factors may modulate metabolic effects of air pollutant exposures. We hypothesized that diets enriched with coconut oil (CO), fish oil (FO), or olive oil (OO) would alter ozone-induced metabolic responses. Male Wistar-Kyoto rats (1-month-old) were fed normal diet (ND), or CO-, FO-, or OO-enriched diets. After eight weeks, animals were exposed to air or 0.8 ppm ozone, 4 h/day for 2 days. Relative to ND, CO- and OO-enriched diet increased body fat, serum triglycerides, cholesterols, and leptin, while all supplements increased liver lipid staining (OO > FO > CO). FO increased n-3, OO increased n-6/n-9, and all supplements increased saturated fatty-acids. Ozone increased total cholesterol, low-density lipoprotein, branched-chain amino acids (BCAA), induced hyperglycemia, glucose intolerance, and changed gene expression involved in energy metabolism in adipose and muscle tissue in rats fed ND. Ozone-induced glucose intolerance was exacerbated by OO-enriched diet. Ozone increased leptin in CO- and FO-enriched groups; however, BCAA increases were blunted by FO and OO. Ozone-induced inhibition of liver cholesterol biosynthesis genes in ND-fed rats was not evident in enriched dietary groups; however, genes involved in energy met...Continue Reading

References

Mar 15, 1997·Annals of the New York Academy of Sciences·W P WatkinsonD L Costa
Jul 9, 2005·The Journal of Endocrinology·Márcio Pereira-da-SilvaLício A Velloso
Feb 27, 2010·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A KrygsmanJ Louw
Mar 23, 2012·American Journal of Physiology. Endocrinology and Metabolism·Hemant PoudyalLindsay Brown
Jun 29, 2013·The International Journal of Biochemistry & Cell Biology·O SchakmanJ P Thissen
Oct 10, 2013·Toxicology and Applied Pharmacology·V BassU P Kodavanti
Apr 4, 2015·Toxicology and Applied Pharmacology·Desinia B MillerUrmila P Kodavanti
May 24, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·K KrügerF C Mooren
Jan 7, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Desinia B MillerUrmila P Kodavanti
Jan 9, 2016·American Journal of Respiratory and Critical Care Medicine·Desinia B MillerUrmila P Kodavanti
Jul 3, 2016·Toxicology and Applied Pharmacology·Desinia B MillerUrmila P Kodavanti
Jun 7, 2017·Advances in Experimental Medicine and Biology·Saad EliasAssy Nimer
Jun 18, 2017·Toxicology and Applied Pharmacology·Andres HenriquezUrmila P Kodavanti
Jan 13, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samantha J SnowUrmila P Kodavanti
Apr 5, 2018·Environmental Health Perspectives·Sarah A LuchtBarbara Hoffmann
Apr 14, 2018·Environment International·Clara MatthiessenUNKNOWN Heinz Nixdorf Recall Study Investigative Group
May 3, 2018·Respiratory Research·T WhyandM E Caplin
May 26, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Ruopeng AnChenghua Guan
May 31, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samantha J SnowUrmila P Kodavanti
Oct 20, 2018·Journal of the American College of Cardiology·Sanjay RajagopalanRobert D Brook
Nov 1, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andres R HenriquezUrmila P Kodavanti
Jan 3, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Melinda H Spooner, Donald B Jump
Jan 19, 2019·Journal of Cachexia, Sarcopenia and Muscle·Anita E M KneppersAnnemie M W J Schols

❮ Previous
Next ❯

Citations

Feb 2, 2021·Toxicology and Applied Pharmacology·Samantha J SnowUrmila P Kodavanti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.