Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit

Biochemical Pharmacology
L MediniC Galli

Abstract

We have studied the effects of semi-synthetic diets rich in either n-9 (olive oil, OO) or n-6 (corn oil, CO), or n-3 (fish oil, FO, as MaxEPA) fatty acids on the levels of major PUFA in platelet lipids, on the generation of inositol phosphates by [3H]inositol labelled platelets after stimulation with thrombin and of thromboxane B2 (TxB2) by platelet rich plasma (PRP) after stimulation with collagen. The predicted elevations of oleic (OA), linoleic (LA) and eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids were observed in platelet lipids of each animal group, but in the MaxEPA fed group accumulation of EPA was associated with depletion of linoleic acid (LA) rather than of arachidonic acid (AA). Basal levels of inositol-tris-phosphate (IP3) in platelets were lowest in the OO group and highest in the CO group, whereas the increment after thrombin stimulation (1 unit/ml NIH) was maximal in the OO group and minimal in the FO group. Instead, when generation of TxB2 by stimulated platelets was evaluated, no appreciable difference among the various groups could be detected, in accordance with the limited modifications of platelet AA content induced by the diets. The overall data indicate that dietary fatty acids modulate the path...Continue Reading

References

Nov 16, 1982·Biochemical and Biophysical Research Communications·M M Billah, E G Lapetina
Nov 15, 1983·Biochemical and Biophysical Research Communications·S Fischer, P C Weber
Nov 17, 1980·Biochemical and Biophysical Research Communications·Y KawaharaY Nishizuka

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Citations

Apr 1, 1994·Cardiovascular Drugs and Therapy·L M SassenP D Verdouw
Mar 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Chih-Chiang ChiuWinston W Shen
Sep 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A L StollW E Severus
Jun 1, 1991·Journal of Neurochemistry·P SimonssonC Alling
Feb 1, 1993·The Journal of Clinical Investigation·R I SperlingD R Robinson
Jan 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C GalliG Galella
Mar 3, 2010·Circulation·Francesco VioliStefania Basili
Apr 1, 1996·Medical Hypotheses·M F McCarty

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