Difference between bacterial and food antigens in mucosal immunogenicity.

Infection and Immunity
A E WoldT Midvetdt

Abstract

The mucosa-associated lymphoid tissue may deviate from its systemic counterpart in being able to discriminate between microbial and nonmicrobial antigens. To study this, the systemic and mucosal antibody responses to bacterial and food antigens were followed in parallel in female rats during two pregnancies and lactation periods. Germfree rats were monocolonized with an Escherichia coli O6K13H1 strain, and their diet was switched to pellets containing large amounts of ovalbumin and beta-lactoglobulin. Antibodies against O6 lipopolysaccharide already appeared in serum and bile 1 week after colonization, and those against type 1 fimbriae appeared a few weeks later. Serum immunoglobulin G antibodies against the E. coli enzyme beta-galactosidase were found in moderate titers in all rats after 16 weeks of exposure. In contrast, few rats had detectable antibody levels against the dietary proteins ovalbumin and beta-lactoglobulin in serum or bile even after 16 weeks of exposure. In the milk, antibodies against E. coli beta-galactosidase and type 1 fimbriae reached the highest titers, while moderate titers were found against the food antigens and against O6 lipopolysaccharide. The difference in immune reactivity against bacterial versu...Continue Reading

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R M Steinman, M D Witmer
Jan 1, 1988·Infection and Immunity·C L WellsR L Simmons
Feb 1, 1988·The Journal of Experimental Medicine·H J de Aizpurua, G J Russell-Jones
Oct 10, 1985·Journal of Immunological Methods·S HusbyS E Svehag
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·P BrandtzaegK Baklien
Jan 1, 1985·International Archives of Allergy and Applied Immunology·P L Lim, D Rowley
Dec 1, 1972·The American Journal of Clinical Nutrition·E S Fubara, R Freter
Jan 1, 1973·Scandinavian Journal of Immunology. Supplement·B Weeke
Jun 1, 1983·Scandinavian Journal of Immunology·U DahlgrenL A Hanson
Dec 16, 1983·Journal of Immunological Methods·C C CzerkinskyA Tarkowski
Jan 1, 1984·Reviews of Infectious Diseases·C A Dinarello
Jan 1, 1984·Journal of Immunoassay·C C CzerkinskyC Gretzer
May 8, 1959·Annals of the New York Academy of Sciences·B E GUSTAFSSON

❮ Previous
Next ❯

Citations

Jan 1, 1991·Immunologic Research·U I DahlgrenT Midtvedt
Sep 1, 1993·FEMS Microbiology Reviews·P Marteau, J C Rambaud
Aug 1, 1996·Gut·J J PowellR P Thompson
Feb 5, 1999·European Journal of Immunology·M R KarlssonU I Dahlgren
Dec 26, 2001·Journal of Pediatric Gastroenterology and Nutrition·Tamara Matysiak-Budnik, Martine Heyman
Jun 24, 2006·Oral Diseases·W SosrosenoG J Seymour
Oct 1, 1996·Antonie van Leeuwenhoek·J M WellsR W Le Page
Jul 1, 1997·Nature Biotechnology·K RobinsonR W Le Page
Apr 22, 2006·Oral Microbiology and Immunology·W SosrosenoG J Seymour
Aug 22, 2003·Oral Microbiology and Immunology·W SosrosenoG J Seymour
Jan 29, 2000·Immunology and Cell Biology·J ChinA Mullbacher
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J BjorkanderL A Hanson
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·A ModelskaV Yusibov
Jul 8, 2003·The British Journal of Nutrition·Hanne R ChristensenHanne Frøkiaer
Jan 23, 1999·Infection and Immunity·W Van den BroeckB M Goddeeris
Jan 1, 1994·FEMS Immunology and Medical Microbiology·J D KuenenH van Dijk
Oct 23, 2001·Research in Veterinary Science·M C RebelattoH Hogenesch
Dec 1, 1991·Journal of Clinical Microbiology·H BrüssowC Mietens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.