Difference between genomic actions of estrogen versus raloxifene in human ovarian cancer cell lines

Oncogene
H SasakiM Ohmichi

Abstract

Although there is growing evidence that estrogens promote tumor progression in epithelial ovarian cancer, the molecular mechanisms accounting for this are still unclear. Selective estrogen receptor modulators (SERMs) mimic estrogen action in certain tissues while opposing it in others. The molecular mechanisms of the effects of SERMs such as raloxifene on the tumor progression of epithelial ovarian cancer are also still unclear. Here, we show that various genomic actions of estrogen differ from those of raloxifene in human ovarian cancer cell lines expressing estrogen receptor alpha (ERalpha). 17beta-Estradiol (E2) induced the gene expression of c-Myc and IGF-1 and increased the binding of ERalpha to the AP1 site of the promoters of c-Myc and IGF-1. ERalpha silencing abolished the E2-stimulated c-Myc expression. E2 induced the recruitment of co-activators such as SRC-1, SRC-3 and CBP to the promoters of c-Myc and IGF-1, and SRC-1 silencing abolished both the E2-stimulated c-Myc expression and cell-cycle progression. In contrast, although raloxifene increased the binding of ERalpha to the AP1 site of the promoters of c-Myc and IGF-1, raloxifene had no effect on the gene expression of c-Myc or IGF-1. Raloxifene induced the recrui...Continue Reading

References

Sep 9, 1992·International Journal of Cancer. Journal International Du Cancer·E M BernsJ A Foekens
Feb 1, 1991·Endocrine Reviews·B R Rao, B J Slotman
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·L J Murphy
Jan 1, 1986·Journal of Steroid Biochemistry·S GreenP Chambon
May 26, 1998·JAMA : the Journal of the American Medical Association·B W WalshP W Anderson
Aug 22, 2001·Lancet·N S Weiss, M A Rossing
Mar 30, 2002·Science·Yongfeng Shang, Myles Brown
Apr 26, 2002·Gynecologic Oncology·Patrick NevenDavid Muram
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Jul 16, 2002·JAMA : the Journal of the American Medical Association·James V LaceyCatherine Schairer
Aug 15, 2003·The Journal of Biological Chemistry·Jun KawagoeHirohisa Kurachi
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Steering Committee
Jul 21, 2004·Gynecologic Oncology·Séverine CunatPascal Pujol
Aug 18, 2004·Cancer Research·Aurélie BardinGwendal Lazennec
Oct 7, 2004·Biochemical and Biophysical Research Communications·Akira OishiHirohisa Kurachi
Dec 21, 2004·Molecular and Cellular Endocrinology·S Hussein-Fikret, P J Fuller
Feb 12, 2005·Science·Chetana M RevankarEric R Prossnitz
Mar 12, 2005·Science·Sylvia Curtis HewittKenneth S Korach

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Citations

Dec 25, 2008·Current Opinion in Oncology·Simon P Langdon, John F Smyth
Sep 8, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jung-Min ChoiHan-Woong Lee
Aug 16, 2011·Molecular and Cellular Endocrinology·Ann E Drummond, Peter J Fuller
Apr 30, 2009·Frontiers in Neuroendocrinology·Marc J TetelThierry D Charlier
Sep 16, 2008·Reproductive Toxicology·Jorgelina VarayoudJorge G Ramos
Nov 1, 2015·The Journal of Clinical Investigation·Jiro KikuchiYusuke Furukawa
Feb 24, 2015·European Journal of Medicinal Chemistry·Lukáš TimkoFerdinand Devínsky
Nov 22, 2012·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Chin-Hsiao Tseng, Farn-Hsuan Tseng
Oct 3, 2017·Biological & Pharmaceutical Bulletin·Tetsuya NomuraNaoki Utoguchi
May 1, 2021·International Journal of Molecular Sciences·Paweł UruskiKrzysztof Książek

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